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2017-03-08

Publication Lists

2017

Julia Vodopiutz, Shuji Mizumoto, Ekkehard Lausch, Antonio Rossi, Sheila Unger, Nikolaus Janocha, Rainer Seidl, Susanne Greber-Platzer, Shuhei Yamada, Thomas Müller, Bernd Jilma, Rudolf Ganger, Andrea Superti-Furga, Shiro Ikegawa, Kazuyuki Sugahara, Andreas R. Janecke,
"Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) deficiency results in a mild skeletal dysplasia and joint laxity"
Human Mutation, 38(1), 34-38, 2017.

2016

Kenji Suzuki, Somasundaram Arumugam, Junji Yokoyama, Yusuke Kawauchi, Yutaka Honda, Hiroki Sato, Yutaka Aoyagi, Shuji Terai, Kazuichi Okazaki, Yasuo Suzuki, Shuji Mizumoto, Kazuyuki Sugahara, Raja Atreya, Markus F. Neurath, Kenichi Watanabe, Taishi Hashiguchi, Hiroyuki Yoneyama, and Hitoshi Asakura
“Pivotal role of carbohydrate sulfotransferase 15 in fibrosis and mucosal healing in mouse colitis”
PLos ONE, 11 (7), e0158967, 2016.


*Florian Job, *Shuji Mizumoto, Laurie Smith, Natario Couser, Ashley Brazil, Howard Saal, Melanie Patterson, Margaret I. Gibson, Sarah Soden, Neil Miller, Isabelle Thiffault, Carol Saunders, Shuhei Yamada, Katrin Hoffmann, Kazuyuki Sugahara, Emily Farrow. (*equal contribution)
"Functional validation of novel compound heterozygous variants in B3GAT3 resulting in severe osteopenia and fractures: expanding the disease phenotype"
BMC Medical Genetics, 17(1), 86, 2016.

2015

Kazuyuki Sugahara, Shuji Mizumoto, and Shuhei Yamada
"Chondroitin sulfate"
In Encyclopedia of Polymeric Nanomaterials (Kobashi, S. and Muellen, K., eds.), Springer-Verlag Berlin Heidelberg, 389-397, 2015.

Shuji Mizumoto, Shuhei Yamada, and Kazuyuki Sugahara
"Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins"
Current Opinion in Structural Biology, 34, 35-42, 2015.

Marina Koutsioumpa, Evangelia Poimenidi, Evangelia Pantazaka, Christina Theodoropoulou, Angeliki Skoura, Vasileios Megalooikonomou, Nelly Kieffer, Jose Courty, Shuji Mizumoto, Kazuyuki Sugahara, and Evangelia Papadimitriou
"Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor"
Molecular Cancer, 14(1), No.19 (16 pages), 2015.

Birgit S. Budde, *Shuji Mizumoto, Ryo Kogawa, Christian Becker, Janine Altmüller, Holger Thiele, Franz Rüschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hämmerle, Wolffang Höhne, Kazuyuki Sugahara, Peter Nürnberg, and Ingo Kennerknecht (*equal contribution)
"Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3"
Human Genetics, 134(7), 691-704, 2015.

Shuhei Yamada
"Role of Hyaluronidases in the Catabolism of Chondroitin Sulfate"
In Adv. Exp. Med. Biol. Vol 842, “Biochemical Roles of Eukaryotic Cell Surface Macromolecules” (Chakrabarti, A. and Surolia, A., eds.), Springer, Heidelberg, 185-197, 2015.

Shuhei Yamada
"Catabolism of Chondroitin Sulfate"
Cell. Mol. Biol. Lett., 20, 196-212, 2015.

Shuji Mizumoto, Shuhei Yamada, and Kazuyuki Sugahara
“Mutations in biosynthetic enzymes for the protein linker region of chondroitin/dermatan/heparan sulfate cause skeletal and skin dysplasias”
BioMed Res. Int., 2015, Article ID 861752, 2015.

Akram Hossain, Fuminori Yamaguchi, Tatsuhiro Matsuo, Ikuko Tsukamoto, Yukiyasu Toyoda, Masahiro Ogawa, Yasuo Nagata, and Masaaki Tokuda
“Rare sugar d-allulose: Potential role and therapeutic monitoring in maintaining obesity and type 2 diabetes mellitus”
Pharmacol. Ther., 155, 49-59, 2015.

2014

Yu Zhao, Tasuku Nakajima, Jing Jing Yang, Takayuki Kurokawa, Jian Liu, Jishun Lu, Shuji Mizumoto, Kazuyuki Sugahara, Nobuto Kitamura, Kazunori Yasuda, A. U. D. Daniels, and Jian Ping Gong
“Proteoglycans and glycosaminoglycans improve toughness of biocompatible double network hydrogelsions”
Advanced Materials, 26(3), 436-442, 2014.

Peraphan Pothacharoen, Sumet Najarus, Jongkolnee Settakorn, Shuji Mizumoto, Kazuyuki Sugahara, and Prachya Kongtawelert
"Effects of sesamin on the biosynthesis of chondroitin sulfate proteoglycans in human articular chondrocytes in primary culture"
Glycoconjugate Journal, 31(3), 221-230, 2014.

Daisuke Kawamura, Tadanao Funakoshi, Shuji Mizumoto, Kazuyuki Sugahara, and Norimasa Iwasaki.
"Sulfation patterns of exogenous chondroitin sulfate affect chondrogenic differentiation of ATDC5 cells"
Journal of Orthopaedic Science, 19(6), 1028-1035, 2014.

Shuji Mizumoto, Shuhei Yamada, and Kazuyuki Sugahara
"Human genetic disorders and knockout mice deficient in glycosaminoglycan"
BioMed Research International, 2014, Article ID 495764, 24 pages, 2014.

Tomoki Kosho, Shuji Mizumoto, and Kazuyuki Sugahara
“Carbohydrate (N-acetyl-D-galactosamine 4-O) sulfotransferase 14 (CHST14)”
Handbook of Glycosyltransferases and Related Genes, (N. Taniguchiet al., eds.). pp. 1135-1148, 2014, Springer.

2013

Shuhei Yamada, Keiichiro Matsushima, Haruo Ura, Nobuyuki Miyamotd, Kazuyuki Sugahara
"Mass preparation of oligosaccharides by hydrolysis of chondroitin sulfate polysaccharides with subcritical water microreaction system"
Carbohydr. Res., 371, 16-21, 2013.

Shuji Mizumoto, Moto Watanabe, Shuhei Yamada, and Kazuyuki Sugahara
"Expression of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase involved in chondroitin sulfate synthesis is responsible for pulmonary metastasis"
BioMed Research International (Journal of Biomedicine and Biotechnology), 2013, Article ID 656319, 9 pages, 2013.

Shuji Mizumoto, Saori Murakoshi, Kittiwan Kalayanamitra, Sarama Sathyaseelan Deepa, Shigeyuki Fukui, Prachya Kongtawelert, Shuhei Yamada, and Kazuyuki Sugahara
"Highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: Insights into the sugar sequences with bioactivities"
Glycobiology, 23 (2), 155-168, 2013.

Hirofumi Kodera, Kazuyuki Nakamura, Hitoshi Osaka, Yoshihiro Maegaki, Kazuhiro Haginoya, Shuji Mizumoto, Mitsuhiro Kato, Nobuhiko Okamoto, Mizue Iai, Yukiko Kondo, Kiyomi Nishiyama, Yoshinori Tsurusaki, Mitsuko Nakashima, Noriko Miyake, Kazuyuki Sugahara, Isao Yuasa, Yoshinao Wada, Naomichi Matsumoto, and Hirotomo Saitsu
“De novo mutations in SLC35A2 encoding a UDP-galactose transporter cause early-onset epileptic encephalopathy”
Human Mutation, 34(12), 1708-1714, 2013.

*Aritoshi Iida, *Pelin Ozlem Simsek-Kiper, *Shuji Mizumoto, Touma Hoshino, Nursel Elcioglu, Eva Horemuzova, Stefan Geiberger, Gozde Yesil, Hulya Kayserili, Gulen Eda Unite, Koray Boduroglu, Shigehiko Watanabe, Hirofumi Ohashi, Yasemin Alanay, Kazuyuki Sugahara, Gen Nishimura, and Shiro Ikegawa (*equal contribution)
“Clinical and radiographic features of the autosomal recessive form of brachyolmia caused by PAPSS2 mutations”
Human Mutation, 34 (10), 1381–1386, 2013.

*Thomas Müller, *Shuji Mizumoto, *Indrajit Suresh, Yoshie Komatsu, Julia Vodopiutz, Munis Dündar, Volker Straub, Arno Lingenhel, Andreas Melmer, Silvia Lechner, Johannes Zschocke, Kazuyuki Sugahara, Andreas R Janecke (*equal contribution)
“Loss of dermatan sulfate epimerase (DSE) function results in musculocontractural Ehlers-Danlos syndrome”
Human Molecular Genetics, 22 (18), 3761-3772, 2013.

*Masahiro Nakajima, *Shuji Mizumoto, *Noriko Miyake, Ryo Kogawa, Aritoshi Iida, Hironori Ito, Hiroshi Kitoh, Aya Hirayama, Hiroshi Mitsubuchi, Osamu Miyazaki, Rika Kosaki, Reiko Horikawa, Angeline Lai, Roberto Mendoza-Londono, Lucie Dupuis, David Chitayat, Andrew Howard, Gabriela F. Leal, Denise Cavalcanti, Yoshinori Tsurusaki, Hirotomo Saitsu, Shigehiko Watanabe, Ekkehart Lausch, Sheila Unger, Luisa Bonafé, Hirofumi Ohashi, Andrea Superti-Furga, Naomichi Matsumoto, Kazuyuki Sugahara, Gen Nishimura and Shiro Ikegawa. (*equal contribution)
“Mutations in B3GALT6, which Encodes a Glycosaminoglycan Linker Region Enzyme, Cause a Spectrum of Skeletal and Connective Tissue Disorders”
American Journal of Human Genetics, 92 (6), 927-934, 2013.

Shuji Mizumoto, Duriya Fongmoon, and Kazuyuki Sugahara
“Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines”
Glycoconjugate Journal, 30 (6), 619-632, 2013 

Shuji Mizumoto, Shiro Ikegawa, and Kazuyuki Sugahara
“Human genetic disorders caused by defective genes encoding biosynthetic enzymes for sulfated glycosaminoglycans”
Journal of Biological Chemistry (Minireview), 288 (16), 10953-10961, 2013.

Shuji Mizumoto
“Reduction of Chondroitin 4-O-Sulfotransferase-1 Expression Causes Costello Syndrome”
Trends in Glycoscience and Glycotechnology, 25 (142), 87-89, 2013.

Shuji Mizumoto and Kazuyuki Sugahara
“Glycosaminoglycans are functional ligands for Receptor for Advanced Glycation End-products (RAGE) in tumors”
FEBS Journal (SPECIAL ISSUE on “Proteoglycan Signaling, Targeting And Therapeutics”), 280 (10), 2462-2470, 2013.

2012

Tomoko Honda, Tomoyuki Kaneiwa, Shuji Mizumoto, Kazuyuki Sugahara, and Shuhei Yamada#
"Hyaluronidases have strong hydrolytic activity toward chondroitin 4-sulfate comparable to that for hyaluronan"
Biomolecules, 2, 549-563, 2012. #Corresponding author.

Tomoyuki Kaneiwa, Anzu Miyazaki, Ryo Kogawa, Shuji Mizumoto, Kazuyuki Sugahara, and Shuhei Yamada#
"Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4)"
J. Biol. Chem., 2012, 2012, 287 (50), 42119-42128. #Corresponding author.

Fumi Kobayashi*, Shuhei Yamada*#, Shuhei Taguwa, Chikako Kataoka, Satomi Naito, Yoshiki Hama, Hideki Tani, Yoshiharu Matsuura, and Kazuyuki Sugahara#
“Specific Interaction of the Envelope Glycoproteins E1 and E2 with Liver Heparan Sulfate Involved in the Tissue Tropismatic Infection by Hepatitis C Virus”
Glycoconjugate J., 29 (4), 211-220, 2012. *These authors contributed equally to the work. #Corresponding authors.

Shuhei Yamada (2012) Chondroitin sulfate-specific novel hydrolase in human. In Adv. Exp. Med. Biol. Vol 749, “Biochemical Roles of Eukaryotic Cell Surface Macromolecules” (Sudhakaran, P. and Surolia, A., eds.), Springer, 47-56, 2012.

Eriko Sakamoto, Yusuke Seino, Ayako Fukami, Naohiro Mizutani, Shin Tsunekawa, Kota Ishikawa, Hidetada Ogata, Eita Uenishi, Hideki Kamiya, Yoji Hamada, Hiroyuki Sato, Norio Harada, Yukiyasu Toyoda, Ichitomo Miwa, Jiro Nakamura, Nobuya Inagaki, Yutaka Oiso, and Nobuaki Ozaki:Ingestion of a Moderate High-sucrose Diet Results in Glucose Intolerance with Reduced Liver Glucokinase Activity and Impaired Glucagon-like Peptide-1 Secretion.
J. Diabetes Invest., 3 (5), 432–440, 2012.

*Shuji Mizumoto, *Jun Takahashi, and Kazuyuki Sugahara (*equal contribution)
“Receptor for Advanced Glycation End Products (RAGE) Functions as a Receptor for Specific Sulfated Glycosaminoglycans, and Anti-RAGE Antibody or The Sulfated Glycosaminoglycans Delivered in vivo Inhibit Pulmonary Metastasis of Tumor Cells”
Journal of Biological Chemistry, 287 (23), 18985-18994, 2012.

Shuji MIZUMOTO and Kazuyuki SUGAHARA
“Bone and Skin Disorders Caused by a Disturbance in the Bioynthesis of Chondroitin Sulfate and Dermatan Sulfate”
In Extracellular matrix: Pathobiology and signaling, (N. Karamanos ed.), Walter De Gruyter, Berlin, Germany, pp. 97-118, 2012.

Kazuyuki SUGAHARA and Shuji MIZUMOTO
“ISCSM2011 Chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis”
Advances in Experimental Medicine and Biology "Biochemical Roles of Eukaryotic Cell Surface Macromolecules", (P. R. Sudhakaran and A. Surolia, eds), Springer, New York, in press, vol. 749, pp. 33-45, 2012, 5/23

Shuji Mizumoto and Kazuyuki Sugahara
“Glycosaminoglycan chain analysis and characterization (Glycosylation/Epimerization)”
Methods in Molecular Biology, “Proteoglycans: Methods and Protocols” (Rédini, Françoise, ed.), vol.836, 99-115, 2012, Humana Press, Springer, New York

2011

Taishi Hashiguchi, Takanari Kobayashi, Duriya Fongmoon, Ajaya Kumar Shetty, Shuji Mizumoto, Nobuyuki Miyamoto, Toshikazu Nakamura, Shuhei Yamada#, and Kazuyuki Sugahara#
“Demonstration of the Hepatocyte Growth Factor Signaling Pathway in the in vitro Neuritogenic Activity of Chondroitin Sulfate from Ray Fish Cartilage”
Biochim. Biophys. Acta, 1810 (4), 406-413, 2011. #Corresponding authors.

Chizuru Akatsu, Shuji Mizumoto, Tomoyuki Kaneiwa, Marco Maccarana, Anders Malmström, Shuhei Yamada#, and Kazuyuki Sugahara#
“Dermatan Sulfate Epimerase 2 Is the Predominant Isozyme in the Formation of the Chondroitin Sulfate/Dermatan Sulfate Hybrid Structure in Postnatal Developing Mouse Brain”
Glycobiology, 21 (5), 565-574, 2011. #Corresponding authors.

Eunmi Kim, Megumi Okumura, Hirofumi Sawa, Tadaaki Miyazaki, Daisuke Fujikura, Shuhei Yamada, Kazuyuki Sugahara, Michihito Sasaki, and Takashi Kimura
“Paradoxical effects of chondroitin sulfate-E on Japanese encephalitis viral infection”
Biochem. Biophys. Res. Commun., 409 (4), 717-722, 2011.

Jiancheng Chen, Shuhei Yamada#, Yoshiki Hama, Ajaya Kumar Shetty, Takanari Kobayashi, Hiroshi Oda, Kosuke Seiki, Eunmi Kim, Takashi Kimura, Naonori Takahashi, Kazuya I. P. J. Hidari, Takashi Suzuki, Yasuo Suzuki, and Kazuyuki Sugahara#
“Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus“
Biochem. Biophys. Res. Commun., 412 (1), 136-142, 2011. #Corresponding authors.

Taishi Hashiguchi, Shuji Mizumoto, Yuko Nishimura, Jun-ichi Tamura, Shuhei Yamada#, and Kazuyuki Sugahara#
“Involvement of HNK-1 sulfotransferase in the biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl tetrasaccharide found in -thrombomodulin from human urine“
J. Biol. Chem., 286 (38), 33003-33011, 2011. #Corresponding authors.

Shuhei Yamada#, Kazuyuki Sugahara, and Suat Özbek
“Evolution of Glycosaminoglycans: Comparative Biochemical Study.”
Commun. Integr. Biol., 4 (2), 150-158, 2011. #Corresponding author.

Mohammad A Hossain, Shigeru Kitagaki, Daisuke Nakano, Akira Nishiyama, Yasunobu Funamoto, Toru Matsunaga, Ikuko Tsukamoto, Fuminori Yamaguchi, Kazuyo Kamitori, Youyi Dong, Yuko Hirata, Koji Murao, Yukiyasu Toyoda, and Masaaki Tokuda:Rare Sugar D-Psicose Improves Insulin Sensitivity and Glucose Tolerance in Type 2 Diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Biochem. Biophys. Res. Commun., 405, 7–12 (2011)

Anurag Purushothaman, Douglas R. Hurst, Claudio Pisano, Shuji Mizumoto, Kazuyuki Sugahara, and Ralph D. Sanderson
“Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype”
Journal of Biological Chemistry, 286 (35), 30377-30383, 2011.

*Sevjidmaa Baasanjav, *Lihadh Al-Gazali, *Taishi Hashiguchi, Shuji Mizumoto, Bjoern Fischer, Denise Horn, Dominik Seelow, Bassam R. Ali, Samir A.A. Aziz, Ruth Langer, Ahmed A.H. Saleh, Christian Becker, Gudrun Nürnberg, Vincent Cantagrel, Joseph G. Gleeson, Delphine Gomez, Jean-Baptiste Michel, Sigmar Stricker, Tom H. Lindner, Peter Nürnberg, Kazuyuki Sugahara, Stefan Mundlos, and Katrin Hoffmann (*equal contribution)
“Faulty initiation of proteoglycan synthesis causes cardiac and joint defects”
American Journal of Human Genetics, 89 (1), 15-27, 2011.

Shuji Mizumoto
“Disorder of Biosynthesis of Dermatan Sulfate Causes a New Type of Ehlers-Danlos Syndrome”
Trends in Glycoscience and Glycotechnology, 23 (132), 197-199, 2011.


2010

Taishi Hashiguchi, Shuji Mizumoto, Shuhei Yamada#, and Kazuyuki Sugahara#
“Analysis of the Structure and Neuritogenic Activity of Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Porcine Fetal Membranes”
Glycoconjugate J., 27 (1), 49-60, 2010. #Corresponding authors.

Tomoyuki Kaneiwa, Shuji Mizumoto, Kazuyuki Sugahara, and Shuhei Yamada#
“Identification of Human Hyaluronidase-4 as a Novel Chondroitin Sulfate Hydrolase That Preferentially Cleaves the Galactosaminidic Linkage in the Trisulfated Tetrasaccharide Sequence”
Glycobiology, 20 (3), 300-309, 2010. #Corresponding author.

Anurag Purushothaman, Toru Uyama, Fumi Kobayashi, Shuhei Yamada, Kazuyuki Sugahara, Alan C. Rapraeger, and Ralph D. Sanderson
“Heparanase Enhanced Shedding of Syndecan-1 by Myeloma Cells Promotes Endothelial Invasion and Angiogenesis”
Blood, 115 (12), 2449-2457, 2010.

Chizuru Akatsu, Duriya Fongmoon, Shuji Mizumoto, Jean-Claude Jacquinet, Prachya Kongtawelert, Shuhei Yamada#, and Kazuyuki Sugahara#
“Development of a Mouse Monoclonal Antibody Against the Chondroitin Sulfate-protein Linkage Region Derived from Shark Cartilage”
Glycoconjugate J., 27 (4), 387-399, 2010. #Corresponding authors.

Noriko Miyake*, Tomoki Kosho*, Shuji Mizumoto*, Tatsuya Furuichi, Atsushi Hatamochi, Yoji Nagashima, Eiichi Arai, Kazuo Takahashi, Rie Kawamura, Keiko  Wakui, Jun Takahashi, Hiroyuki Kato, Hiroshi Yasui, Tadao Ishida, Hirofumi Ohashi, Gen Nishimura, Masaaki Shiina, Hirotomo Saitsu, Yoshinori Tsurusaki, Hiroshi Doi, Yoshimitsu Fukushima, Shiro Ikegawa, Shuhei Yamada, Kazuyuki Sugahara, Naomichi Matsumoto
“Loss of decorin dermatan sulfate impairing collagen bundle formation in a new type of Ehlers-Danlos syndrome”
Hum. Mut., 31 (8), 966-974, 2010. *These authors contributed equally to the work.

Patrizia Adamczyk, Claudia Zenkert, Prakash G. Balasubramanian, Shuhei Yamada, Saori Murakoshi, Kazuyuki Sugahara, Jung Shan Hwang, Takashi Gojobori, Thomas W. Holstein and Suat Özbek
“A Non-sulfated Chondroitin Stabilizes Membrane Tubulation in Cnidarian Organelles”
J. Biol. Chem., 285 (33), 25613-25623, 2010.

Jun-ichi Tamura, Tomomi Nakamura-Yamamoto, Yuko Nishimura, Shuji Mizumoto, Jun Takahashi, and Kazuyuki Sugahara
“Synthesis of the glycosaminoglycan-protein linkage tetrasaccharide peptide moieties of betaglycan, which serve as amino sugar acceptor for enzymatic glycosyl transfer”
Carbohydrate Research, 2010年10月13日、345(15), 2115-2123.

Shuji Mizumoto
“Roles of Dermatan Sulfate Epimerase”
Trends in Glycoscience and Glycotechnology, 22(127), 256-258, 2010.


2009

Shuhei Yamada#, Masako Onishi, Reiko Fujinawa, Yuko Tadokoro, Koji Okabayashi, Makoto Asashima, and Kazuyuki Sugahara
“Structural and Functional Changes of Sulfated Glycosaminoglycans in Xenopus laevis during Embryogenesis”
Glycobiology, 19 (5), 488-498, 2009. #Corresponding author.

Daniela Virgintino, Daniela Perissinotto, Francesco Girolamo, Maria T. Mucignat, Luisa Montanini, Mariella Erede, Tomoyuki Kaneiwa, Shuhei Yamada, Kazuyuki Sugahara, Luisa Roncali, and Roberto Perris
“Differential Distribution of Aggrecan Isoforms in Perineuronal Nets of the Human Cerebral Cortex.”
J. Cell. Mol. Med., 13 (9b), 3151-3173, 2009.

Gerdy B. ten Dam, Shuhei Yamada, Fumi Kobayashi, Anurag Purushothaman, Els M.A. van de Westerlo, Johan Bulten, Anders Malmström, Kazuyuki Sugahara, Leon F. Massuger, and Toin H. van Kuppevelt
“Dermatan Sulfate Domains Defined by the Novel Antibody GD3A12, in Normal Tissues and Ovarian Adenocarcinomas.”
Histochem. Cell Biol., 132 (1), 117-127, 2009.

Ajaya Kumar Shetty, Takanari Kobayashi, Shuji Mizumoto, Masaki Narumi, Yoshiaki Kudo, Shuhei Yamada#, and Kazuyuki Sugahara#
“Isolation and Characterization of a Novel Chondroitin Sulfate from Squid Liver Integument Rich in N-Acetylgalactosamine(4,6-O-disulfate) and Glucuronate(3-O-sulfate) Residues.”
Carbohydr. Res., 344 (12), 1526-1532, 2009. #Corresponding authors.

Basappa, Sengottuvelan Murugan, Kazuki N. Sugahara, Chun Man Lee, Gerdy B. ten Dam, Toin H. van Kuppevelt, Masayuki Miyasaka, Shuhei Yamada#, and Kazuyuki Sugahara#
“Involvement of Chondroitin Sulfate E in the Liver Metastasis of Osteosarcoma Cells.”
Glycobiology, 19 (7), 735-742, 2009. #Corresponding authors.

Iwao Takahashi, Naoya Noguchi, Koji Nata, Shuhei Yamada, Tomoyuki Kaneiwa, Shuji Mizumoto, Takayuki Ikeda, Kazushi Sugihara, Masahide Asano, Takeo Yoshikawa, Akiyo Yamauchi, Nausheen Jamal Shervani, Akira Uruno, Ichiro Kato, Michiaki Unno, Kazuyuki Sugahara, Shin Takasawa, Hiroshi Okamoto, and Akira Sugawara
“Important Role of Heparan Sulfate in Postnatal Islet Growth and Insulin Secretion”
Biochem. Biophys. Res. Commun., 383 (1), 113-118, 2009.

Shuhei Yamada#, Shuji Mizumoto, and Kazuyuki Sugahara
“Chondroitin Hydrolase in Caenorhabditis elegans.”
Trends Glycosci. Glycotechnol., 21 (119), 149-162, 2009. #Corresponding author.


*Shuji Mizumoto, *Tadahisa Mikami, Daiki Yasunaga, Naoki Kobayashi, Hajime Yamauchi, Ayumi Miyake, Nobuyuki Itoh, Hiroshi Kitagawa, and Kazuyuki Sugahara (*equal contribution)
“Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish”
Biochemical Journal, 419(2), 387-399, 2009.


Beyhan Tuysuz, Shuji Mizumoto, Kazuyuki Sugahara, Ahmet Çelebi, Stefan Mundlos, Seval Turkmen
“Omani type spondyloepiphyseal dysplasia with cardiac involvement caused by a missense mutation in CHST3”
Clinical Genetics, 75 (4), 375-383, 2009.

2008

Fuchuan Li*, Shuhei Yamada*, Basappa, Ajaya K. Shetty, Makiko Sugiura, and Kazuyuki Sugahara
“Determination of Iduronic Acid and Glucuronic Acid in Sulfated Chondroitin/Dermatan Hybrid Chains by 1H-Nuclear Magnetic Resonance Spectroscopy.”
Glycoconjugate J., 25 (7), 603-610, 2008. *These authors contributed equally to the work.

Tomoyuki Kaneiwa*, Shuhei Yamada*#, Shuji Mizumoto, Adriana M. Montaño, Souhei Mitani and Kazuyuki Sugahara#
“Identification of a Novel Chondroitin Hydrolase in Caenorhabditis elegans.”
J. Biol. Chem., 283 (22), 14971-14979, 2008. *These authors contributed equally to the work. #Corresponding authors.

Mirjam H.H. van Roij*, Shuji Mizumoto*, Shuhei Yamada, Tim Morgan, M.B. Tan-Sindhunata, H. Meijers-Heijboer, J.I.L.M. Verbeke, David Markie, Kazuyuki Sugahara, and Stephen P. Robertson
“Spondyloepiphyseal Dysplasia, Omani Type: Further Definition of the Phenotype.”
Am. J. Med. Genet., 146A (18), 2376-2384, 2008. *These authors contributed equally to the work.

Fuchuan Li*, Gerdy B. ten Dam*, Sengottuvelan Murugan, Shuhei Yamada, Taishi Hashiguchi, Shuji Mizumoto, Kayoko Oguri, Minoru Okayama, Toin H. van Kuppevelt, and Kazuyuki Sugahara
“Involvement of Highly Sulfated Chondroitin Sulfate in the Metastasis of the Lewis Lung Carcinoma Cells.”
J. Biol. Chem., 283 (49), 34294-34304, 2008. *These authors contributed equally to the work.

Shuhei Yamada and Kazuyuki Sugahara
“Potential Therapeutic Application of Chondroitin Sulfate/Dermatan Sulfate.” 
Current Drug Discovery Technologies, 5 (4), 289-301, 2008.

Kazuyuki Sugahara and Shuhei Yamada
『Experimental Glycoscience Glycochemistry』 (Taniguchi, N. et al., eds.) (“Microsequencing of Functional Chondroitin Sulfate Oligosaccharides.”)
Springer, Tokyo, Japan, 64-69, 2008


Shuji Mizumoto, Hiroshi Kitagawa、
“Heparan sulfate synthases and related genes”
Experimental Glycoscience “Glycobiology” (Taniguchi N., Suzuki A., Ito Y., Narimatsu H., Kawasaki T., Hase S., eds), pp. 59-63, 2008, Springer, Tokyo, Japan

*Christina Malavaki, *Shuji Mizumoto, Nikos Karamanos, Kazuyuki Sugahara (*equal contribution)
“Recent advances in the structural study of functional chondroitin sulfate and dermatan sulfate in health and disease”
Connective Tissue Research, 49 (3), 133-139, 2008.


2007

Alexandra Abramsson, Sindhulakshmi Kurup, Marta Busse, Shuhei Yamada, Per Lindblom, Edith Schallmeiner, Denise Stenzel, Dominique Sauvaget, Johan Ledin, Maria Ringvall, Ulf Landegren, Lena Kjellén, Göran Bondjers, Jin-ping Li, Ulf Lindahl, Dorothe Spillmann, Christer Betsholtz, and Holger Gerhardt
“Defective N-Sulfation of Heparan Sulfate Proteoglycans Limits PDGF-BB Binding and Pericyte Recruitment in Vascular Development.”
Genes Dev., 21 (3), 316 - 331, 2007.

Sarama Sathyaseelan Deepa, Kittiwan Kalayanamitra, Yumi Ito, Prachya Kongtaweelert, Shigeyuki Fukui, Shuhei Yamada, Tadahisa Mikami, and Kazuyuki Sugahara
“Novel Sulfated Octa- and Decasaccharides from Squid Cartilage Chondroitin Sulfate-E: Sequencing and Application for Determination of the Epitope Structure of Monoclonal Antibody MO-225.”
Biochemistry, 46 (9), 2453-2465, 2007.

Sarama S. Deepa, Shuhei Yamada, Shigeyuki Fukui, and Kazuyuki Sugahara
“Structural Determination of Novel Sulfated Octasaccharides Isolated from Chondroitin Sulfate of Shark Cartilage and Their Application for Characterizing Monoclonal Antibody Epitopes.”
Glycobiology, 17 (6), 631-645, 2007.

Shuhei Yamada*, Hideto Morimoto*, Toshitaka Fujisawa, and Kazuyuki Sugahara
“Glycosaminoglycans in Hydra magnipapillata (Hydrozoa, Cnidaria): Demonstration of Chondroitin in the Developing Nematocyst, Sting Organelle, and Structural Characterization of Glycosaminoglycans.”
Glycobiology, 17 (8), 886-894, 2007. *These authors contributed equally to the work.

Duriya Fongmoon*, Ajaya Kumar Shetty*, Basappa, Shuhei Yamada, Makiko Sugiura, Prachya Kongtawelert, and Kazuyuki Sugahara
“Chondroitinase-mediated Degradation of Rare 3-O-Sulfated Glucuronic Acid in Functional Oversulfated Chondroitin Sulfate K and E.”
J. Biol. Chem., 282 (51), 36895-36904, 2007. *These authors contributed equally to the work.

Yasuo Terauchi, Iseki Takamoto, Naoto Kubota, Junji Matsui, Ryo Suzuki, Kajuro Komeda, Akemi Hara, Yukiyasu Toyoda, Ichitomo Miwa, Shinichi Aizawa, Shuichi Tsutsumi, Yoshiharu Tsubamoto, Shinji Hashimoto, Kazuhiro Eto, Akinobu, Nakamura, Mitsuhiko Noda, Kazuyuki Tobe, Hiroyuki Aburatani, Ryozo Nagai, and Takashi Kadowaki
Glucokinase and IRS-2 are required for compensatory beta-cell hyperplasia in response to high-fat diet-induced insulin resistance
J. Clin. Invest. 117 (1), 246-257 (2007)


Anurag Purushothaman, Junko Fukuda, Shuji Mizumoto, Gerdy B. ten Dam, Toin H. van Kuppevelt, Hiroshi Kitagawa, Tadahisa Mikami, and Kazuyuki Sugahara、
“Functions of chondroitin sulfate/dermatan sulfate chains in brain development: Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7”
Journal of Biological Chemistry, 282 (27), 19442-19452, 2007.


Hiroki Nakagawa, Yoichiro Hama, Toshihisa Sumi, Su-Chen Li, Karol Maskos, Kittiwan Kalayanamitra, Shuji Mizumoto, Kazuyuki Sugahara, and Yu-The Li.
“Occurrence of a non-sulfated chondroitin proteoglycan in the dried saliva of collocalia swiftlets (edible bird's nest)”
Glycobiology, 17 (2), 157-164, 2007.


2006

Shuhei Yamada# and Akira Seko#
“Preface for the Special Issue Entitled “The research front line of the biosynthesis and recognition of acidic sugar chains”.”
Trends Glycosci. Glycotechnol., 18 (101), 163-164, 2006. #Corresponding authors.

Takashi Nishio, Yukiyasu Toyoda, Masayuki Hiramatsu, Taku Chiba, and Ichitomo Miwa
Decline in glucokinase activity in the arcuate nucleus of streptozotocin-induced diabetic rats
Biol. Pharm. Bull. 29 (2), 216-219 (2006)

*Chie Mitsunaga, *Tadahisa Mikami, Shuji Mizumoto, Junko Fukuda, and Kazuyuki Sugahara (*equal contribution)
“Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum: Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases”
Journal of Biological Chemistry, 281 (28), 18942-18952, 2006.

2005

Xingfeng Bao, Tadahisa Mikami, Shuhei Yamada, Andreas Faissner, Takashi Muramatsu, and Kazuyuki Sugahara
“Heparin-binding Growth Factor, Pleiotrophin, Mediates Neuritogenic Activity of Embryonic Pig Brain-derived Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains toward Embryonic Mouse Hippocampal Neurons in Culture.”
J. Biol. Chem., 280 (10), 9180-9191, 2005.

Kicki Bergefall, Edward Trybala, Maria Johansson, Toru Uyama, Satomi Naito, Shuhei Yamada, Hiroshi Kitagawa, Kazuyuki Sugahara, and Tomas Bergström
“Chondroitin Sulfate Characterized by the E-disaccharide Unit Is a Potent Inhibitor of Herpes Simplex Virus Infectivity and Provides the Virus Binding Sites on gro2C Cells.”
J. Biol. Chem., 280 (37), 32193 - 32199, 2005. Xingfeng Bao, Shuji Nishimura,


Shuji Mizumoto, Hiroshi Kitagawa, and Kazuyuki Sugahara、
“Biosynthesis of Heparin and Heparan sulfate”
Chemistry and Biology of Heparin and Heparan sulfate (Hari G. Garg, Robert J. Linhardt and Charles A. Hales, eds.), pp. 203-243, 2005, Elsevier, Oxford, UK.

*Shuji Mizumoto, *Toru Uyama, Tadahisa Mikami, Hiroshi Kitagawa, and Kazuyuki Sugahara (*equal contribution)
“Biosynthetic pathways for differential expression of functional chondroitin sulfate and heparan sulfate”
Handbook of Carbohydrate Engineering (Kevin J. Yarema, ed.), CRC Press (Taylor & Francis Group), pp. 289-324, 2005, Boca Raton, FL.

2004

Xingfeng Bao,Shuji Nishimura,Tadahisa Mikami, Shuhei Yamada, Nobuyuki Itoh, and Kazuyuki Sugahara
“Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Embryonic Pig Brain, Which Contain a Higher Proportion of L-Iduronic Acid Than Those from Adult Pig Brain, Exhibit Neuritogenic and Growth Factor-binding Activities.”
J. Biol. Chem., 279 (11), 9765-9776, 2004.

Yuko Umehara, Shuhei Yamada, Shuji Nishimura, Junichi Shioi, Nikolaos K. Robakis, and Kazuyuki Sugahara
“Chondroitin Sulfate of Appican, the Proteoglycan Form of Amyloid Precursor Protein, Produced by C6 Glioma Cells Interacts with Heparin-binding Neuroregulatory Factors.”
FEBS Lett., 557 (1-3), 233-238, 2004.

Shuhei Yamada, Marta Busse, Momoyo Ueno, Olivia G. Kelly, William C. Skarnes, Kazuyuki Sugahara, and Marion Kusche-Gullberg
“Embryonic Fibroblasts with a Gene Trap Mutation in Ext1 Produce Short Heparan Sulfate Chains.”
J. Biol. Chem., 279 (31), 32134-32141, 2004.

Akiko Kinoshita-Toyoda, Shuhei Yamada, Stuart M. Haslam, Kay-Hooi Khoo, Makiko Sugiura, Howard R. Morris, Anne Dell, and Kazuyuki Sugahara
“Structural Determination of Five Novel Tetrasaccharides Containing 3-O-Sulfated D-Glucuronic Acid and Two Rare Oligosaccharides Containing a -D-Glucose Branch Isolated from Squid Cartilage Chondroitin Sulfate E.”
Biochemistry, 43 (34), 11063-11074, 2004.

S. S. Deepa, Shuhei Yamada, Masahiro Zako, Olga Goldberger, and Kazuyuki Sugahara
“Chondroitin Sulfate Chains on Syndecan-1 and Syndecan-4 from Normal Murine Mammary Gland Epithelial Cells Are Structurally and Functionally Distinct and Co-operate with Heparan Sulfate Chains to Bind Growth Factors: A Novel Function to Control Binding of Midkine, Pleiotrophin and Basic Fibroblast Growth Factor.”
J. Biol. Chem., 279 (36), 37368-37376, 2004.

Maki Inoue, Yoshiyuki Sakuraba, Hiromi Motegi, Naoto Kubota, Hideaki Toki, Junko Matsui, Yukiyasu Toyoda, Ichitomo Miwa, Yasuo Terauchi, Takashi Kadowaki、Yutaka Shigeyama、Masato Kasuga、Takeshi Adachi、Naomi Fujimoto、Rie Matsumoto、keiko Tsuchihashi、Tomoko Kagami、Ayako Inoue、Hideki Kaneda、Junko Ishijima、Hiroshi Masuya、Tomohiro Suzuki、Shigeharu Wakana、Yoichi Gondo、Osamu Minowa、Toshihiko Shiroishi、Tetsuo Noda
A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.
Hum. Mol. Genet. 13 (11), 1147-1157 (2004)

Ichitomno Miwa, Yukiyasu Toyoda, and Sumio Yoshie
Glucokinase and Glycemic Disease: From Basics to Novel Terapeutics
Ed. By F. M. Matschinsky and M. A. Magnuson
pp.350-259, Basel, Karger (2004)

2003

Shuhei Yamada and Kazuyuki Sugahara
Meth. Mol. Biol., 213,『Capillary Electrophoresis of Carbohydrates』(Thibault, P., and Honda, S., eds.) (“Preparation of Oligosaccharides from Sulfated Glycosaminoglycans Using Bacterial Enzymes.”)
Humana Press Inc., Totowa, New Jersey, 71-78, 2003


*Tadahisa Mikami, *Shuji Mizumoto, Naohide Kago, Hiroshi Kitagawa, and Kazuyuki Sugahara (*equal contribution)
“Specificities of three distinct chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as acceptor: Implication of differential roles in dermatan biosynthesis”
Journal of Biological Chemistry, 278 (38), 36115-36127, 2003.

2002

Hiroto Kawashima, Kazuyuki Atarashi, Mayumi Hirose, Jun Hirose, Shuhei Yamada, Kazuyuki Sugahara, and Masayuki Miyasaka
“Oversulfated Chondroitin/Dermatan Sulfates Containing GlcA1/IdoA1-3GalNAc(4,6-O-disulfate) Interact with L- and P-Selectin and Chemokines”
J. Biol. Chem., 277 (15), 12921-12930, 2002.

Shuhei Yamada, Yukihiko Okada, Momoyo Ueno, Satomi Iwata, S. S. Deepa, Shuji Nishimura, Masaki Fujita, Irma Van Die, Yoshio Hirabayashi, and Kazuyuki Sugahara
“Determination of the Glycosaminoglycan-protein Linkage Region Oligosaccharide Structures of Proteoglycans from Drosophila melanogaster and Caenorhabditis elegans.”
J. Biol. Chem., 277 (35), 31877-31886, 2002.

Yukihiko Okada*, Shuhei Yamada*, Minako Toyoshima, Jian Dong, Motowo Nakajima, and Kazuyuki Sugahara
“Structural Recognition by Recombinant Human Heparanase That Plays Critical Roles in Tumor Metastasis: Hierachical Sulfate Groups with Differential Effects and the Essential Target Disulfated Trisaccharide Sequence.”
J. Biol. Chem., 277 (45), 42488-42495, 2002. *These authors contributed equally to the work.

Kazuyuki Sugahara and Shuhei Yamada
『Analytical techniques to evaluate the structure and functions of natural polysaccharides, glycosaminoglycans』(Volpi, N., ed.) (“Analysis of Chondroitin Sulfate. The Repeating Disaccharide Region for Specific Protein Binding and the Protein Attachment Region Critical in Biosynthesis.”)
Research Signpost, Trivandrum, Kerala, India, 79-114, 2002

2001

Hiromi Sakaguchi, Miki Watanabe, Chikako Ueoka, Eiko Sugiyama, Tamotsu Taketomi, T., Shuhei Yamada, and Kazuyuki Sugahara
“Isolation of Reducing Oligosaccharide Chains from the Chondroitin/Dermatan Sulfate-protein Linkage Region and Preparation of Analytical Probes by Fluorescent Labeling with 2-Aminobenzamide.”
J. Biochem., 129 (19), 107-118, 2001.

Akiko Kinoshita, Shuhei Yamada, Stuart M. Haslam, Howard R. Morris, Anne Dell, and Kazuyuki Sugahara
“Isolation and Structural Determination of Novel Sulfated Hexasaccharides from Squid Cartilage Chondroitin Sulfate E That Exhibits Neuroregulatory Activities.”
Biochemistry, 40 (42), 12654-12665, 2001.

Momoyo Ueno, Shuhei Yamada, Masahiro Zako, Merton Bernfield, and Kazuyuki Sugahara
“Structural Characterization of Heparan Sulfate and Chondroitin Sulfate of Syndecan-1 Purified from Normal Murine Mammary Gland Epithelial Cells: Common Phosphorylation of Xylose and Differential Sulfation of Galactose in the Protein Linkage Region Tetrasaccharide Sequence.”
J. Biol. Chem., 276 (31), 29134-29140, 2001.

Kazunori Tsuchida, Junichi Shioi, Shuhei Yamada, Garen Boghosian, Anfan Wu, Hongying Cai, Kazuyuki Sugahara, and Nikolaos K. Robakis
“Appican, the Proteoglycan Form of the Amyloid Precursor Protein, Contains the Chondroitin Sulfate E in the Repeating Disaccharide Region and 4-O-Sulfated Galactose in the Linkage Region.”
J. Biol. Chem., 276 (40), 37155-37160, 2001.

Akihiko Shiraishi, Yuichiro Yamada, Yoshiyuki Tsuura, Shimpei Fujimoto, Katsushi Tsukiyama, Eri Mukai, Yukiyasu Toyoda, Ichitomo Miwa, and Yutaka Seino
A novel glucokinase regulator in pancreatic B-cells. Prexursor of propionyl-CoA carboxylase Bsubunit interacts with glucokinase and augments its activity
J. Biol. Chem. 276 (4), 2325-2328 (2001)

Yukiyasu Toyoda, Aya Tsuchida, Eriko Iwami, and Ichitomo Miwa:
Toxic effect of troglitazone on cultured rat hepatocytes
Life Sci., 68 (16), 1867-1876 (2001)

Yukiyasu Toyoda, Aya Tsuchida, Eriko Iwami, Hiroaki Shironoguchi, and Ichitomo Miwa
Regulation of Hepatic Glucose Metabolism by Translocation of Glucokinase between the Nucleus and the Cytoplasm in Hepatocytes
Horm. Metab. Res. 33 (6), 329-336 (2001)

2000

Junko Kishibe, Shuhei Yamada, Yukihiko Okada, Junji Sato, Aya Ito, Kaoru Miyazaki, and Kazuyuki Sugahara
“Structural Requirements of Heparan Sulfate for the Binding to the Tumor-derived Adhesion Factor/Angiomodulin That Induces Cord-like Structures to ECV-304 Human Carcinoma Cells.”
J. Biol. Chem., 275 (20), 15321-15329, 2000.

Kazuyuki Sugahara and Shuhei Yamada
“Structure and Function of Oversulfated Chondroitin Sulfate Variants: Unique Sulfation Patterns and Neuroregulatory Activities.”
Trends Glycosci. Glycotechnol., 12, 321-349, 2000.

Fumihiko Maekawa, Yukiyasu Toyoda, Norihiro Torii, Ichitomo Miwa, Robert C. Thompson, Douglas L. Foster, Shinji Tsukahara, Hiroko Tsukamura, and Kei-ichiro Maeda
Localization of glucokinase-like immunoreactivity in the rat lower brain stem: for possible location of brain glucose-sensing mechanisms.
Endocrinology, 141, 375-384 (2000)

Yukiyasu Toyoda, Yuki Ito, Keiichiro Tanigawa, and Ichitomo Miwa
Impairment of glucokinase translocation in cultured hepatocytes from OLETF and GK rats, animal models of type 2 diabetes.
Arch. Histol. Cytol., 63 (3), 243-248 (2000)

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