主な研究業績
医薬品の放出に関する研究 - マトリックス製剤からの放出 -
．
§ Release from or through a Wax Matrix
System MEMO top
a modified Higuchi equation
１．Yorinobu Yonezawa, Sumio Ishida, Hisakazu
Sunada：
I. Basic Release Properties of the Wax
Matrix System
Chem. Pharm. Bull., 49(11), 1448 - 1451 (2001)
２．Yorinobu Yonezawa, Sumio Ishida, Shinobu
Suzuki, Hisakazu Sunada：
II. Basic Properties of Release from or
through the Wax Matrix Layer
Chem. Pharm. Bull.,50 (2), 220 - 224 (2002)
３．Yorinobu Yonezawa, Sumio Ishida, Shinobu
Suzuki, Hisakazu Sunada：
III. Basic Properties of Release through
the Wax Matrix Layer
Chem. Pharm. Bull., 50 (6), 814 - 817 (2002)
４．Yorinobu Yonezawa, Sumio Ishida, Shinobu
Suzuki, Hisakazu Sunada：
IV. Generalized Expression of the Release
Process for a Reservoir Device Tablet
Chem. Pharm. Bull., 50 (9), 1219 - 1222 (2002)
5．Yorinobu Yonezawa, Sumio Ishida, Hisakazu
Sunada：
V. Applicability of the Square-oot Time
Law Equation for Release from a Wax Matrix
Tablet
Chem. Pharm. Bull., 51 (8), 904 - 908 (2003)
6．Yorinobu Yonezawa, Sumio Ishida, Hisakazu Sunada:
VI. Analysis and Prediction of the Entire
Release Process of the Wax Matrix Tablet
Chem. Pharm. Bull., 53( 8), 915 -918 (2005)
§ Release from or through a Polymer Matrix
System
1) Atsuko Fukui, Ryuta Fujii, Yorinobu
Yonezawa, and Hisakazu Sunada
Analysis of the Release Process of Phenylpropranolamine
Hydrochloridw from Ethylcellulose Matrix
Granules
Chem. Pharm. Bull., 50 (11), 1439 - 1442 (2002)
2) Atsuko Fukui, Ryuta Fujii, Yorinobu
Yonezawa, and Hisakazu Sunada
Analysis of the Release Process of Phenylpropranolamine
Hydrochloridw from Ethylcellulose Matrix
Granules
II. Effects of the Binder Solution on the
Release Process
Chem. Pharm. Bull., 52 (3), 298 - 302 (2004)
3) Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa,
Hisakazu Sunada:
Analysis of Release Process of Phenylpropanolamine
Hydrochloride from Ethylcellulose Matrix Granules
III.Effects of the Dissolution Condition on the
Release Process
Chem. Pharm. Bull., 54(8), 1091 -1096 (2006)
4) Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa,
Hisakazu Sunada：
Analysis of the Release Process of Phenylpropanolamine
Hydrochloride from Ethylcellulose Matrix
Granules .
IV. Evaluation of the Controlled Release
Properties for in Vivo and in Vitro Release
Systems
Chem. Pharm. Bull., 55( 11), 1569 - 1573 (2007
5) Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa,
Hisakazu Sunada：
Analysis of the Release Process of
Phenylpropanolamine Hydrochloride from Ethylcellulose
Matrix Granules .
V. Release Properties of Ethylcellulose
Layered Matrix Granules
Chem. Pharm. Bull., 56(4), 525 - 529 (2008)
医薬品の溶解に関する研究 - 粒子と錠剤の溶解過程 -
．
§ Dissolution of Solid Dosage Form. MEMO top
an another derivation of Hixson-Crowell equations
１．Yorinobu Yonezawa, Itaru Shinohara, Akinobu
Otsuka, Hisakazu Sunada：
Dissolution and Simulation Curves for Log-Normal
Particle-Size-Distributed Model System
Chem. Pharm. Bull., 38 (11), 3107 - 3111 (1990)
２．Yorinobu Yonezawa, Kenji Shirakuara,
Akinobu Otsuka, Hisakazu Sunada：
II. Equations for the Dissolution of Nondisintegrating
Tablet under the Sink Condition
Chem. Pharm. Bull., 39 (3), 769 - 772 (1991)
３．Yorinobu Yonezawa, Kenji Shirakuara,
Akinobu Otsuka, Hisakazu Sunada：
III. Equations for the Dissolution of
a Nondisintegrating Single Component Tablet
under a Nonsink Condition
Chem. Pharm. Bull., 39 (12), 3355 - 3358 (1991)
４．Yorinobu Yonezawa, Itaru Shinohara, Midori
Sasaki, Akinobu Otsuka, Hisakazu Sunada：
IV. Equations for the Non-sink Dissolution
of a Monodisperse System
Chem. Pharm. Bull., 42 (2), 349 - 353 (1994)
５．Yorinobu Yonezawa, Shuichi Kawase, Midori
Sasaki, Itaru Shinohara, Hisakazu Sunada：
V. New Form Equations for the Non-sink
Dissolution of a Monodisperse System
Chem. Pharm. Bull., 43 (2), 304 -310 (1995)
６．Yorinobu Yonezawa, Shuichi Kawase, Midori
Sasaki, Akiko Wada, Hisakazu Sunada：
VI. Dissolution of Nondisintegrating Single
Component Tablet under Non-Sink Condition
Chem. Pharm. Bull., 43 (11), 1961 -1965 (1995)
７．Yorinobu Yonezawa, Shuichi Kawase, Yuji
Jinde, Hisakazu Sunada：
VII. Effect of Shape on the Dissolution
of Nondisintegrating Single Component Tablet
under Non-sink Condition
Chem. Pharm. Bull., 44 (5), 1043 -1048 (1996)
医薬品の溶解に関する研究 - 表面積変化と溶解過程 -
．
§ Changes of Surface Area in the Dissolution
Process of Crystalline Substances MEMO top
１．Hisakazu Sunada, Akio Yamamoto, Akinobu
Otsuka, Yorinobu Yonezawa：
Changes of Surface Area in the Dissolution
Process of Crystalline Substances
Chem. Pharm. Bull., 36 (7), 2557 - 2561 (1988)
２．Hisakazu Sunada, Itaru Shinohara, Akinobu
Otsuka, Yorinobu Yonezawa：
II. Dissolution and Simulation Curves
for Mixed Systems of Sieved Particles
Chem. Pharm. Bull., 37 (2), 467 - 470 (1989)
３．Hisakazu Sunada, Itaru Shinohara, Akinobu
Otsuka, Yorinobu Yonezawa：
III. Dissolution and Simulation Curves
for Symmetrical Particle-Size Distributed
Model Systems
Chem. Pharm. Bull., 37 (5), 1362 - 1365 (1989)
４．Hisakazu Sunada, Itaru Shinohara, Akinobu
Otsuka, Yorinobu Yonezawa：
IV. Dissolution and Simulation Curves
Estimated from Changes of Surface Area and
Cube Root Law
Chem. Pharm. Bull., 37 (7), 1889 - 1894 (1989)
５．Yorinobu Yonezawa, Itaru Shinohara, Akinobu
Otsuka, Hisakazu Sunada：
V. Dissolution and Simulation Curves for
Log-Normal Particle-Size-Distributed Model
Systems
Chem. Pharm. Bull., 38 (4), 1024 - 1026 (1990)
６．米澤頼信、篠原 格、大塚昭信、砂田久一：
技術資料 結晶性粒子の溶解シミュレーション
粉体工学会誌、27 (9), 621 - 625 (1990)
７．米澤頼信、篠原 格、大塚昭信、砂田久一：
技術資料 結晶性粒子の溶解シミュレーション（第２報）
粉体工学会誌、28 (9), 567 - 571 (1991)
界面化学に関する研究 - 水溶液中におけるグリチルリチンの物理化学的性質 -
．
§ Physico-Chemical Properties of Glycyrrhizic
Acid in Aqueous Media MEMO top
１．大塚昭信，米澤頼信，伊庭克英，巽 恒治，砂田久一：
界面活性作用と会合体形成
薬学雑誌, 96 (2), 203 - 208 (1976)
２．Akinobu Otsuka, Yorinobu Yonezawa, Yasuhiko
Nakamura：
Effect on Flocculation-Deflocculation Behavior
of Suspensions of Sulfathiazole and Graphite
J. Pharm. Sci., 67 (2), 151 - 154 (1978)
３．米澤頼信，大塚昭信：
水に難溶な色素および医薬品に対する可溶化作用
薬学雑誌, 101 (9), 829 - 835 (1981)
４．米澤頼信，大塚昭信：
オレイン酸の乳化
薬学雑誌, 103 (2), 203 - 208 (1983)
５．米澤頼信，砂田久一，大塚昭信，中垣正幸：
グリチルリチンとコール酸ナトリウムとの混合溶液の臨界ミセル濃度
薬学雑誌, 103 (10), 1085 - 1090 (1983)
６．米澤頼信，大塚昭信，砂田久一：
グリチルリチンの乳化作用とその乳濁液の安定性
香粧会誌, J. Jpn. Cosmet. Sci. Soc., 8 (1), 61 - 66 (1984)
その他
1．Jens Thuro Carstensen, Yorinobu Yonezawa：
Dissolution Profiles in Column Dissolution
J. Pharm. Sci., 75 (8), 764 - 768 (1986)
２．Hisakazu Sunada, Yoshiko Hirai, Yorinobu
Yonezawa, Akinobu Otsuka：
Flocculation Studies of Granulated Stearyl
Alcohol on the Surface of Aqueous Media.
II. Flocculation-Deflocculation Mechanism
in a Two-Dimensional System
Chem. Pharm. Bull., 36 (9), 3584 -3588 (1988)
３．Haruo Sekizaki, Kazumi Danjo, Hiroshi
Eguchi, Yorinobu Yonezawa, Hisakazu Sunada,
Akinobu Otsuka：
Solid-State Interaction of Ibuprofen with
Polyvinylpyrrolidone
Chem. Pharm.Bull., 43 (6), 988 - 993 (1995)
4. Yunxia Bi, Hisakazu Sunada, Yorinobu Yonezawa,
Kazumi Danjo, Akinobu Otsuka, Kotaro Iida：
Preparation and Evaluation of a Compress
Tablet Rapidly Disintegrating in the Oral
Cavity.
Chem. Pham. Bull., 44(11), 2121-2127 (1996)
5. Yasuhiro Shimada, Mayu Sunada, Mari Mizuno, Yorinobu Yonezawa,
Hisakazu Sunada, Kei Takebayashi, Masahiko
Yokosuka, Haruki Kimura:
Measurement of the adhesive force of fine
particle on tablet surface and method of
their removal
Drug Development and Industrial Pharmacy, 26(2), 149-158 (2000)
6. Yasuhiro Shimada, Yorinobu Yonezawa, Hisakazu
Sunada,
Measurement and Evaluation of the Adhesive
Force between Particles by the Direct Separation
Method
J. Pharm. Sci., 92( 3), 526-534 (2003)
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