研究業績

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学会報告

<日本薬学会第144年会、令和6年3月29日、横浜>
・Functional analyses of immune checkpoint molecule, VISTA, in malignant chest tumors
 大野乃愛、柳澤 聖
・Molecular functional analyses of immune checkpoint molecule, VISTA, in breast cancer
 青木奏里、柳澤 聖
 * 学生優秀発表賞受賞

<第69回日本薬学会東海支部総会、令和5年7月8日、名古屋>
・急性リンパ球性白血病におけるIKAROS分子の機能解析
 荻本祐也、柳澤 聖
・膵臓がんにおける免疫チェックポイント分子の機能解析
 早川 政、柳澤 聖

<日本薬学会第143年会、令和5年3月26日、札幌>
・Proteomic identification of potential biomarkers of malignant pulmonary mesothelioma
 Yanagisawa K, Ono N, Aoki K

<第68回日本薬学会東海支部総会、令和4年7月9日、名古屋>
・Functional analyses of IK6 generating knockout cells of B-cell acute lymphoblastic leukemia
 Ogimoto Y, Yanagisawa K
・Exploration of novel molecular function of SMAD4 in colorectal cancer
 Ogimoto Y, Iinuma M, Yanagisawa K

<日本薬学会第142年会、令和4年3月26日、名古屋>
・ヒトB細胞急性リンパ芽球性白血病細胞株におけるIkarosアイソフォーム6(IK6)のノックアウトモデルによるIK6の役割の解析
 荻本祐也、近藤梨沙、柳澤 聖
                
<日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術学会2021、令和3年10月30日、津>
・Exploration of novel molecular function of SMAD4 in colorectal cancer
 Iinuma M, Kondo-Ida L, Yanagisawa K
・Functional analyses of IK6 generating knockout cells of B-cell acute lymphoblastic leukemia
 Ogimoto Y, Kondo-Ida L, Yanagisawa K

<第80回日本癌学会学術総会、令和3年9月30日、横浜>
・Proteomic identification of potential biomarkers of malignant pleural mesothelioma
 Kondo-Ida L, Yanagisawa K
・Exploration of novel molecular function of SMAD4 in colorectal cancer
 Iinuma M, Lisa Kondo-Ida L, Yanagisawa K
・Exploration of functional significance of TTF-1 in drug resistance in lung adenocarcinoma
 Nishimae A, Kondo-Ida L, Yanagisawa K
・Functional analyses of IKAROS isoform 6 (IK6) generating knockout cells of B-cell acute lymphoblastic leukemia
 Ogimoto Y, Kondo-Ida L, Yanagisawa K

<2020 ASCO Annual Meeting、May 29, 2020、Chicago, USA>
・Hase T, Yanagisawa K, Fukatsu A, Kimura T, Morise M, Nakatochi M, Ando M, Kondo M, Saka H, Saito H, Hasegawa Y, et al.
PREDICT1: An observational study for identifying blood biomarkers associated with clinical benefit from carboplatin and pemetrexed (CbP) treatment in patients with non-squamous (NS) Non-small cell lung cancer (NSCLC)(CJLSG1201).

原著論文

・Tazaki A, Nishadhi ASM D, Li A, Zhang L, Maw H T, Kondo-Ida L, Yanagisawa K, Kato M
Progression from in vivo validation to in vitro screening in hazard assessment for leukoderma-inducible chemicals
Environ Pollut. 1:356:124508. (2024 Sep)

・Hase T, Hara T, Kimura T, Kojima E, Abe T, Horio Y, Goto Y, Yanagisawa K, Ando M, Ando Y, Kondo M, Ishii M, H Yoshinori, et al.
Adjustment of creatinine clearance for carboplatin dosing in Calvert's formula and clinical efficacy for lung cancer
Cancer Med. 12(15):15955-15969. (2023 Aug)

・Iwai M, Kajino T, Nakatochi M, Yanagisawa K, Hosono Y, Isomura H, Shimada Y, et al.
Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer.
Oncogene. 42(5):364-373. (2023 Jan)

・Isomura H, Taguchi A, Kajino T, Asai N, Nakatochi M, Kato S, Suzuki K, Yanagisawa K, Suzuki M, Fujishita T, Yamaguchi T, Takahashi M, et al.
Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator
Cancer Sci. 112(4):1614-1623 (2021 Jan)

・Sudo M, Hashimoto K, Yoshinaga M, Azimi MD, Fayaz SH, Hamajima N, Kondo-Ida L, Yanagisawa K, Kato M.
Lithium promotes malignant transformation of nontumorigenic cells in vitro
Sci Total Environ. 744:140830 (2020 Nov)

・Suzuki M, Cao K, Kato S, Mizutani N, Tanaka K, Arima C, Tai MC, Nakatani N, Yanagisawa K, Takeuchi T, Shi H, Mizutani Y, Tomida S, et al.
CERS6 required for cell migration and metastasis in lung cancer
J Cell Mol Med. 24(20):11949-11959 (2020 Oct)

・Kajino T, Shimamura T, Gong S, Yanagisawa K, lda L, Nakatochi M, Griesing S, Shimada Y, et al.
Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter–enhancer interaction
EMBO Journal. 38:1–13 (2019 Sep)

・Liu Z, Yanagisawa K, Griesing S, Iwai M, Kano K, Hotta N, Kajino T, et al.
TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.
Oncogene. 36(26):3740-48. (2017 Jan)

・Tai MC, Yanagisawa K, Nakatochi M, Hotta N, Hosono Y, Kawaguchi K, Naito M, Taniguchi H, Yokoi K, et al.
Blood-borne miRNA profile-based diagnostic classifier for lung adenocarcinoma.
Sci Rep. 10(6):31389 (2016 Aug)

・Ida L, Yamaguchi T, Yanagisawa K, Kajino T, Shimada Y, Suzuki M and *Takahashi T.
Receptor tyrosine kinase-like orphan receptor 1, a target of NKX2-1/TTF-1 lineage-survival oncogene, inhibits apoptosis signal-regulating kinase 1-mediated pro-apoptotic signaling in lung adenocarcinoma.
Cancer Sci. 107:155-61 (2016 Feb)

・Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, Hotta N, Shimada Y, Isomura H, et al.
ROR1 sustains caveolae and survival signaling as a scaffold of cavin-1 and caveolin-1.
Nat Commun. 7:10060 (2016 Jan)

・NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression.
Yamaguchi T, Hosono Y, Yanagisawa K, Takahashi T.
Cancer Cell. 10;23(6):718-23. (2013 Jun)

・NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
Yamaguchi T, Yanagisawa K, Sugiyama R, Hosono Y, Shimada Y, Arima C, Tomida S, Osada H, et al.
Cancer Cell. 21(3):348-61. (2012 Mar)

・MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis.
Hosono Y, Yamaguchi T, Mizutani E, Yanagisawa K, Arima C, Tomida S, Shimada Y, Hiraoka M, Kato S, Yokoi K, et al.
EMBO J. 18;31(2):481-93. (2012 Jan)

・Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress-response pathways.
Yanagisawa K, Konishi H, Arima C, Tomida S, Takeuchi T, Shimada Y, Yatabe Y, Mitsudomi T, Osada H, Takahashi T.
Cancer Res. 70(23):9949-58. (2010 Dec)

・Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1.
Tanaka H, Yanagisawa K, Shinjo K, Taguchi A, Maeno K, Tomida S, Shimada Y, Osada H, Kosaka T, Matsubara H, Mitsudomi T, Yatabe Y, et al.
Cancer Res. 67(13):6007-11. (2007 Jul)

・A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer.
Yanagisawa K, Tomida S, Shimada Y, Yatabe Y, Mitsudomi T, Takahashi T.
J Natl Cancer Inst. 99(11):858-67. (2007 Jun)

・Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.
Takeuchi T, Tomida S, Yatabe Y, Kosaka T, Osada H, Yanagisawa K, Mitsudomi T, Takahashi T.
J Clin Oncol. 24(11):1679-88. (2006 Apr)

・Proteomic patterns of tumour subsets in non-small-cell lung cancer.
Yanagisawa K, Shyr Y, Xu BJ, Massion PP, Larsen PH, White BC, Roberts JR, Edgerton M, Gonzalez A, Nadaf S, Moore JH, Caprioli RM, Carbone DP.
Lancet. 362(9382):433-9. (2003 Aug)

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