衛生化学研究室 ( HYGIENIC CHEMISTRY )
| 教授 | 小嶋仲夫 （Professor, Nakao Kojima, Ph.D.） |
|---|---|
| 助手 | 戸田千登世 （Instructor, Chitose Toda, B.S.） |
| 助手 | 植田康次 （Instructor, Koji Ueda, Ph.D.） |
| ① | 環境化学物質の環境動態・代謝と内分泌撹乱作用・変異原性発現およびその制御に関する研究 |
|---|---|
| ② | 食品衛生・環境汚染に関する研究 |
| Yoshinori Okamoto, Atsushi Suzuki, Koji Ueda, Chihiro Ito, Masataka Itoigawa, Hiroshi Furukawa, Tsutomu Nishihara and Nakao Kojima：Anti-estrogenic activity of prenylated isoflavones from Millettia pachycarpa: implications for pharmacophores and unique mechanisms
J. Health Sci., 52 (2), 186-191 (2006) |
| Jin Seok Kang, Keiichirou Morimura, Chitose Toda, Hideki Wanibuchi, Min Wei, Nakao Kojima and Shoji Fukushima：Testicular toxicity of DEHP, but not DEHA, is elevated under conditions of thioacetamide-induced liver damage
Reprod. Toxicol., 21 (3), 253-259 (2006) |
| Chihiro Ito, Masataka Itoigawa, Minako Kumagaya, Yoshinori Okamoto, Koji Ueda, Tsutomu Nishihara, Nakao Kojima and Hiroshi Furukawa：Isoflavonoids with antiestrogenic activity from Millettia pachycarpa
J. Nat. Prod., 96, 138-141 (2006) |
| Yoshinori Okamoto, Tomohiro Hayashi, Shinpei Matsunami, Koji Ueda, Chitose Toda, Shosuke Kawanishi and Nakao Kojima：Formation of DNA damaging product from light-irradiated nonylphenol
J. Health Sci., 52, 91-95 (2006) |
| Yosuke Oyama, Chitose Toda, Yoshinori Okamoto, Koji Ueda, Kiyomatsu Hashizume and Nakao Kojima：Isolation of phthalate ester-degradable bacteria from river water by acclimation to di-n-butyl phthalate or mono-n-butyl phthalate
名城大学総合研究所総合学術研究論文集，4, 73-78 (2005) |
| Chitose Toda, Takafumi Uchida, Kaoru Midorikawa, Mariko Murata, Yusuke Hiraku, Yoshinori Okamoto, Koji Ueda, Nakao Kojima, and Shosuke Kawanishi: DNA damage by ethylbenzenhydroperoxide formed from carcinogenic ethylbenzene by sunlight irradiation. Biochem. Biophys. Res. Commun,304,638-642 (2003) |
| Yoshinori Okamoto, Chitose Toda, Koji Ueda, Kiyomatsu Hashizume, Kazuo Itoh, and Nakao Kojima: Endocrine disrupting effects of plasticizers acquired by light-irradiation. J. Res. Inst. Meijo Univ., 2,45-50 (2003) |
| Yoshinori Okamoto, Chitose Toda, Shoko Abe, Taeko Hirose, Koji Ueda, Kiyomatsu Hashizume, and Nakao Kojima: Products variation of phthalate esters in environmental biodegradation. J. Res. Inst. Meijo Univ., 3,77-83 (2004) |
| Yoshinori Okamoto, Kana Okajima, Chitose Toda, Koji Ueda, Kiyomatsu Hashizume, Kazuo Itoh, and Nakao Kojima： Novel estrogenic microsomal metabolites fromphthalate esters. J. Health Sci., 50,556-560（2004） |
| Chitose Toda, Yoshinori Okamoto, Koji Ueda, Kiyomatsu Hashizume, Kazuo Itoh, and Nakao Kojima：Unequivocal estrogen receptor-binding affinity of phthalate esters featured with ring hydroxylation and proper alkyl chain size. Arch. Biochem. Biophys., 431,16-21（2004） |
| Kaoru Midorikawa, Takafumi Uchida, Yoshinori Okamoto, Chitose Toda, Yoshie Sakai, Koji Ueda, Yusuke Hiraku, Mariko Murata, Shosuke Kawanishi, and Nakao Kojima：Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage. Chem. Biol. Interact.,150, 271-281（2004） |
| Yosuke Oyama, Chitose Toda, Yoshinori Okamoto, Koji Ueda, Kiyomatsu Hashizume, and Nakao Kojima: Isolation of phthalate ester-degradable bacteria from river water by acclimation to di-n-butyl phthalate or mono-n-butyl phthalate. J. Res. Inst. Meijo Univ., 4,73-78 (2005) |
| Jin Seok Kang, Keiichirou Morimura, Chitose Toda, Hideki Wanibuchi, Min Wei, Nakao Kojima and Shoji Fukushima: Testicular toxicity of DEHP, but not DEHA, is elevated under conditions of thioacetamide-induced liver damage Reprod. Toxicol.,(in press) |
| Chihiro Ito, Masataka Itoigawa, Minako Kumagaya, Yoshinori Okamoto, Koji Ueda, Tsutomu Nishihara, Nakao Kojima, and Hiroshi Furukawa:Isoflavonoids with antiestrogenic activity from Millettia pachycarpa. J. Nat. Prod. (in press) |
| Yoshinori Okamoto, Tomohiro Hayashi, Shinpei Matsunami, Koji Ueda, Chitose Toda, Shosuke Kawanishi, and Nakao Kojim: Formation of DNA damaging product from light-irradiated nonylphenol. J. Health Sci. (in press). |
| Yoshinori Okamoto, Tomohiro Hayashi, Chitose Toda, Koji Ueda, Kiyomatsu Hashizume, Kazuo Itoh, Jun-ichi Nishikawa, Tsutomu Nishihara and Nakao Kojima: Formation of estrogenic products from environmental phthalate esters under light exposure. Chemosphere (in press). |
| Yoshinori Okamoto, Atsushi Suzuki, Koji Ueda, Chihiro Ito, Masataka Itoigawa, Hiroshi Furukawa, Tsutomu Nishihara and Nakao Kojima: Anti-estrogenic activity of prenylated isoflavones from Millettia pachycarpa: implications for pharmacophores and unique mechanisms. J. Health Sci. (in press). |
| 小嶋 仲夫（分担執筆）：化学物質の毒性
健康と環境 第1版（日本薬学会編），pp.297-302，東京化学同人（平成18年3月） |
| 小嶋 仲夫（分担執筆）：最新公衆衛生学 第3版 pp.302-323, 廣川書店，平成16年2月 |
| 小嶋 仲夫（編集，分担執筆）：新しい衛生薬学 第6版 廣川書店，平成17年3月 |
| 小嶋 仲夫（分担執筆）：衛生・健康科学辞典 日本薬学会編 丸善，平成17年2月 |
