薬化学研究室 (MEDICINAL CHEMISTRY)
| 教 授 | 北垣伸治 (Professor Shinji Kitagaki, Ph.D.) |
|---|---|
| 助教 | 武永尚子 (Assistant Professor Naoko Takenaga, Ph.D.) |
| ① | 新規な骨格に基づく機能性分子の開発研究 |
|---|---|
| ② | 天然物合成を指向した多成分連結反応及びone-pot合成法の開発研究 |
| ③ | 植物資源に含まれる新規抗がん物質および抗発がんプロモーターに関する研究 |
| ④ | ES・iPS細胞分化に作用する活性分子に関する研究 |
| Shinji Kitagaki, Takahiro Ueda, and Chisato Mukai ：Planar Chiral [2.2]Paracyclophane-based Bis(thiourea) Catalyst: Application to Asymmetric Henry Reaction.
Chem. Commun .,49, 4030-4032 (2013) |
| Shinji Kitagaki, Yuu Ohta, Ryohei Takahashi, Mika Komizu, and Chisato Mukai ：Planar Chiral [2.2]Paracyclophane-based Phosphine-Brønsted Acid Catalysts Bearing Exceptionally High Reactivity for Aza-Morita-Baylis-Hillman Reaction.
Tetrahedron Lett .,54, 384-386 (2013) |
| Chihiro Ito, Tomiyasu Murata, Hugh T.-W. Tan, Norio Kaneda, Hiroshi Furukawa, and Masataka Itoigawa ：Rotenoid Derivatives from Derris trifoliata with Nitric Oxide Production Inhibitory Activity.
Nat. Prod. Commun .,7(11), 1479-1482 (2012) |
| Shinji Kitagaki, Mikihito Kajita, Syu Narita, and Chisato Mukai ：Cu-Promoted [2+2] Cycloaddition of 1,4-Bisallenes.
Org. Lett .,14, 1366-1369 (2012) |
| Chihiro Ito, Masataka Itoigawa, Keisuke Nakao, Tomiyasu Murata, Norio Kaneda, and Hiroshi Furukawa ：Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia .
J. Nat. Med .,66, 357-361 (2012) |
| Shinji Kitagaki, Yuu Ohta, Shoichirou Tomonaga, Ryohei Takahashi, and Chisato Mukai ：Synthesis of Planar Chiral Pseudo-ortho-substituted Aryl[2.2]paracyclophanes by Stepwise Successive Palladium-catalyzed Coupling Reactions.
Tetrahedron: Asymmetry .,22, 986-991 (2011) |
| Takuya Matsui, Chihiro Ito, Makita Oda, Masataka Itoigawa, Kazuhisa Yokoo, Tadashi Okada, and Hiroshi Furukawa ：Lapachol suppresses cell proliferation and secretion of interleukin-6 and plasminogen activator inhibitor-1 of fibroblasts derived from hypertrophic scars.
J. Pharm. Pharmacol .,63, 960-966 (2011) |
| Shinji Kitagaki, Mika Komizu, and Chisato Mukai ：Can the Crabbe Homologation Be Successfully Applied to the Synthesis of 1,3-Disubstituted Allenes?
Synlett .,, 1129-1132 (2011) |
| Fuyuhiko Inagaki, Shinji Kitagaki, and Chisato Mukai ：Construction of Diverse Ring Systems Based on Allene-Multiple Bond Cycloaddition.
Synlett .,, 594-614 (2011) |
| Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai, and Emi Nakashima ：Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier.
Drug Metab. Dispos.,38 (9), 1576-1581 (2010) |
| Shinji Kitagaki, Satoshi Teramoto, Yuu Ohta, Harumi Kobayashi, Mika Takabe, and Chisato Mukai ：Chemistry of Allenic/Propargylic Anions Generated by Base Treatment of Sulfonylallenes: Synthesis of 1-Alkynyl-1-sulfonylcycloalkanes and Cycloalkanols.
Tetrahedron .,66 , 3687-3694 (2010) |
| Takamasa Kawamura, Fuyuhiko Inagaki, Syu Narita, Yasuhito Takahashi, Shuichi Hirata, Shinji Kitagaki, and Chisato Mukai ：Rhodium(I)-Catalyzed Intramolecular Carbonylative [2+2+1] Cycloadditions and Cycloisomerizations of Bis(sulfonylallene)s.
Chem. Eur. J .,16, 5173-5183 (2010) |
| Yoshiaki Miyake, Chihiro Ito, Harukuni Tokuda, Toshihiko Osawa, and Masataka Itoigawa ：Evaluation of Flavoglaucin, Its Derivatives and Pyranonigrins Preduced by Molds Used in Fermented Foods for Inhibiting Tumor Promotion.
Biosci. Biotechnol. Biochem .,74(5), 1120-1122 (2010) |
| Fuyuhiko Inagaki, Syu Narita, Takuma Hasegawa, Shinji Kitagaki, and Chisato Mukai ：Rhodium(I)-Catalyzed Intramolecular Carbonylative [2+2+1] Cycloaddition of Bis(allene)s: Bicyclo[6.3.0]undecadienones and Bicyclo[5.3.0]decadienones.
Angew. Chem. Int. Ed.,48, 2007-2011 (2009) |
| 北垣伸治：第9章 ラジカル反応、基礎有機化学問題集（廣田耕作、片岡貞、西出喜代治 編集）.
pp. 147-152. 廣川書店（平成25年3月） |
| 向智里、北垣伸治、稲垣冬彦：非対称な二量体天然物の効率的合成に挑む.
化学, 2011, 66, 68-69. |
| 北垣伸治、稲垣冬彦、向智里：アレンと多重結合間の分子内付加環化反応.
有機合成化学協会誌, 2009, 67, 618-627. |