Publications
2015
Tobe T., Ueda K., Ando M., Okamoto Y., Kojima N.: Thiol-mediated multiple mechanisms centered on selenodiglutathione determine selenium cytotoxicity against MCF-7 cancer cells. J. Biol. Inorg. Chem., in press
Okamoto Y., Tobe T., Ueda K., Takada T., Kojima N.: Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats. J. Toxicol. Sci., in press
2014
Ueda K., Makino R., Tobe T., Okamoto Y., Kojima N.: Effects of organic and inorganic mercury(II) on gene expression via DNA conformational changes. Fund. Toxicol. Sci. 1, 73-79 (2014). [Online]
Okashita N., Kumaki Y., Ebi K., Nishi M., Okamoto Y., Nakayama M., Hashimoto S., Nakamura T., Sugasawa K., Kojima N., Takada T., Okano M., Seki Y.: PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells. Development 141, 269-280 (2014). [PubMed]
Taniguchi Y., Tobe T., Hayami H., Okamoto Y., Ueda K., Takada T., Kojima N.: Neural differentiation of pluripotent stem cells and application for metal-induced neural toxicity study. Yakugaku Zasshi 134, 793-795 (2014). [PubMed]
Tobe T., Ueda K., Okamoto Y., Ando M., Nishida H., Itoh K., Kojima K.: Roles of glutathione-mediated metabolites in the anti-tumor effects of selenium. J. Res. Inst. Meijo Univ. 13, 35-40 (2014).
Tobe T., Okamoto Y., Takada T., Kojima N.: A simple and convenient synthesis of a stable isotope-labeled 5-hydroxymehtyl-2’-deoxycytidine, the sixth base in mammalian DNA. J. Res. Inst. Meijo Univ. 13, 19-25 (2014).
飯田耕太郎、大津史子、永松 正、長谷川洋一、湯川和典、丹羽敏幸、吉田 勉、井藤千裕、加藤美紀、武田直仁、杉浦道治、植田康次、間宮隆吉、吉田謙二、灘井雅行、岡本浩一、二改俊章、小嶋仲夫：薬学部6年次の基礎学力を強化するための教育に関する評価－平成24年度を中心として－. 名城大学教育年報 8, 9-16（2014）.
飯田耕太郎、田口忠雄、永松 正、長谷川洋一、早川伸樹、吉田 勉、伊東亜紀雄、井藤千裕、大津史子、加藤美紀、杉浦道治、武田直仁、植田康次、奥田知将、間宮隆吉、吉田謙二、灘井雅行、岡本浩一：薬学部5年次の基礎知識の補強を目的とした学習支援に関する評価と考察. 名城大学教育年報 8, 17-24（2014）.
2013
Okamoto Y., Nakai T., Ando M., Ueda K., Kojima N.: Induction of the anticancer effects of cisplatin platinum(IV) derivatives against cisplatin-resistant human ovarian cancer cells. J. Res. Inst. Meijo Univ. 12, 35-41 (2013).
Ueda K., Ando M., Okamoto Y., Kojima N.: Manganese neurotoxicity: Interplay with iron in catecholaminergic oxidative stress. J. Res. Inst. Meijo Univ. 12, 75-80 (2013).
Okamoto Y., Ushida M., Taniguchi Y., Takada T., Kojima N.: Effects of genistein, kaempferol and daidzein on neural differentiation of mouse embryonic stem cells.
J. Res. Inst. Meijo Univ. 12, 81-90 (2013).
2012
Liu X., Suzuki N., Laxmi Y.R.S., Okamoto Y., Shibutani S.: Anti-breast cancer potential of daidzein in rodents. Life Sci. 91, 415-419 (2012). [PubMed]
2011
Okamoto Y., Ueda K., Kojima N.: Potential risks of phathalate esters: Acquisition of endocrine-disrupting activity during environmental and metabolic processing. J. Health Sci. 57, 497-503 (2011). Invited Review. ［J-Stage］
Okamoto Y., Toda C., Ueda K., Hashizume K., Kojima N.: Transesterification in the microbial degradation of phthalate esters. J. Health Sci. 57, 293-299 (2011). [J-Stage]
Nishino Y., Ando M., Makino R., Ueda K., Okamoto Y., Kojima N.: Different mechanisms between copper and iron in catecholamines-mediated oxidative DNA damage and disruption of gene expression in vitro. Neurotox. Res. 20, 84-92 (2011).
[PubMed]
Ando M., Ueda K., Okamoto Y., Kojima N.: Combined effects of manganese, iron, copper, and dopamine on oxidative DNA damage. J. Health Sci. 57, 204-209 (2011). [J-Stage]
Ando M., Nishida H., Ueda K., Itoh K., Okamoto Y., Kojima N.: Preparation of oligoselenodiglutathiones and their suppressive effects on oxidative DNA damage induced by catechol and copper. J. Health Sci. 57, 72-77 (2011). [J-Stage]
Nakai T., Ando M., Okamoto Y., Ueda K., Kojima N.: Modulation of oxidative DNA damage and DNA-crosslink formation induced by cis-diammine-tetrachloro-platinum(IV) in the presence of endogenous reductants. J. Inorg. Biochem. 105, 1-5 (2011). [PubMed]
Suzuki N., Liu X., Laxmi Y.R.S., Okamoto K., Kim H.J., Zhang G., Chen J.J., Okamoto Y., Shibutani S.: Anti-breast cancer potential of SS5020, a novel benzopyran antiestrogen. Int. J. Cancer 128, 974-982 (2011). [PubMed]
2010
Ando M., Nishida H., Nishino Y., Ohbayashi M., Ueda K., Okamoto Y., Kojima N.: Carbonyl side-chain of catechol compounds is a key structure for the suppression of copper-associated oxidative DNA damage in vitro. Toxicol. Lett. 199, 213-217 (2010). [PubMed]
Nishida H., Ando M., Itoh K., Ueda K., Nishida Y., Okamoto Y., Toda C., Kojima N.: Production of polyselenodipenicillamines, unique selenium compounds. Chem. Pharm. Bull. 58, 957-960 (2010). [PubMed]
Ando M., Nishida H., Itoh K., Okamoto Y., Ueda K., Kojima N.: Penicillamine selenotrisulfide suppressed DNA strand breaks and oxidative DNA damage in vitro. J. Res. Inst. Meijo Univ. 9, 27-33 (2010).
Laxmi Y.R.S., Liu X., Suzuki N., Kim S.Y., Okamoto K., Kim H.J., Zhang G., Chen J.J., Okamoto Y., Shibutani S.: Anti-breast cancer potential of SS1020, a novel antiestrogen lacking estrogenic and genotoxic actions. Int. J. Cancer 127, 1718-1726 (2010). [PubMed]
Okamoto Y., Liu X., Suzuki N., Okamoto K., Kim H.J., Laxmi Y.R.S., Sayama K., Shibutani S.: Equine estrogen-induced mammary tumors in rats. Toxicol. Lett. 193, 224-228 (2010). [PubMed]
2009
Ando M., Ueda K., Makino R., Nishino Y., Nishida H., Toda C., Okamoto Y., Kojima N.: Involvement of DNA conformational change induced by rearrangement of copper-coodination geometry in oxidative DNA damage caused by copper and dopamine. J. Health Sci. 55, 319-323 (2009). [J-Stage]
Toda C., Ando M., Ueda K., Hashizume K., Kojima N.: Oxidative DNA damage induced by main stream smoke and side stream smoke of cigarette. J. Res. Inst. Meijo Univ. 8, 47-52 (2009).
Ueda K.: Effect of environmental chemicals on genes and the expression. Yakugaku Zasshi 129, 1501-1506 (2009). Invited Review. [PubMed]
2008
Okamoto Y., Hayashi T., Matsunami S., Ueda K., Kojima N.: Combined activation of methyl paraben by light irradiation and esterase metabolism toward oxidative DNA damage. Chem. Res. Toxicol. 21, 1594-1599 (2008). [PubMed]
Kusu R., Oishi A., Kakizawa K., Kimura T., Toda C., Hashizume K., Ueda K., Kojima N.: Effects of phthalate ester derivatives including oxidized metabolites on coactivator recruiting by PPARα and PPARγ. Toxicol. in Vitro 22, 1534–1538 (2008). [PubMed]
Okamoto Y., Chou P.-H., Kim S.Y., Suzuki N., Laxmi Y.R.S., Okamoto K., Liu X., Matsuda T., Shibutani S.: Oxidative DNA damage in XPC-knockout and its wild mice treated with equine estrogen. Chem. Res. Toxicol. 21, 1120-1124 (2008). [PubMed]
Okamoto Y., Liu X., Suzuki N., Okamoto K., Sekimoto M., Laxmi Y.R.S., Shibutani S.: Increased antitumor potential of the raloxifene prodrug, raloxifene diphosphate. Int. J. Cancer 122, 2142-2147 (2008). [PubMed]
Ando M., Ueda K., Makino R., Komatsu Y., Nakai T., Nishino Y., Mizuno H., Obayashi M., Kojima N.: Conformational change and oxidative damage of DNA induced by copper-catechol redox system. J. Res. Inst. Meijo Univ. 7, 81-88 (2008).
2007
Yasui M., Suzuki N., Liu X., Okamoto Y., Kim S.Y., Laxmi Y.R.S., Shibutani S.: Mechanism of translesion synthesis past an equine estrogen-DNA adduct by Y-family DNA polymerases. J. Mol. Biol. 371, 1151-1162 (2007). [PubMed]
Kusu R., Toda C., Okamoto Y., Tozuka Y., Ueda K., Kojima N.: Structural properties of estrogen receptor ligand obtained by study of hydroxylated phthalate ester derivatives. Environ. Toxicol. Pharmacol. 24, 311-315 (2007). [ScienceDirect]
2006
Hayashi T., Okamoto Y., Ueda K., Kojima N.: Formation of estrogenic products from benzophenone after exposure to sunlight. Toxicol. Lett. 167, 1-7 (2006). [PubMed]
Nabae K., Doi Y., Takahashi S., Ichihara T., Toda C., Ueda K., Okamoto Y., Kojima N., Tamano S., Shirai T.: Toxicity of di(2-ethylhexyl)phthalate (DEHP) and di(2-ethylhexyl)adipate (DEHA) under conditions of renal dysfunction induced with folic acid in rats: enhancement of male reproductive toxicity of DEHP is associated with an increase of the mono-derivative. Reprod. Toxicol. 22, 411-417 (2006). [PubMed]
Okamoto Y., Hayashi T., Toda C., Ueda K., Hashizume K., Itoh K., Nishikawa J.-I., Nishihara T., Kojima N.: Formation of estrogenic products from environmental phthalate esters under light exposure. Chemosphere 64, 1785-1792 (2006). [PubMed]
Okamoto Y., Suzuki A., Ueda K., Ito C., Itoigawa M., Furukawa H., Nishihara T., Kojima N.: Anti-estrogenic activity of prenylated isoflavones from Millettia pachycarpa: implications for pharmacophores and unique mechanisms. J. Health Sci. 52, 186-191 (2006). [J-Stage]
Okamoto Y., Hayashi T., Matsunami S., Ueda K., Toda C., Kawanishi S., Kojima N.: Formation of DNA damaging product from light-irradiated nonylphenol. J. Health Sci. 52, 91-95 (2006). [J-Stage]
Ito C., Itoigawa M., Kumagaya M., Okamoto Y., Ueda K., Nishihara T., Kojima N., Furukawa H.: Isoflavonoids with antiestrogenic activity from Millettia pachycarpa. J. Nat. Prod. 69, 138-141 (2006). [PubMed]
Kang J.S., Morimura K., Toda C., Wanibuchi H., Wei M., Kojima N., Fukushima S.: Testicular toxicity of DEHP, but not DEHA, is elevated under conditions of thioacetamide-induced liver damage. Reprod Toxicol. 21, 253-259 (2006). [PubMed]
2005
Oyama Y., Toda C., Okamoto Y., Ueda K., Hashizume K., Kojima N.: Isolation of phthalate ester-degradable bacteria from river water by acclimation to di-n-butyl phthalate or mono-n-butyl phthalate. J. Res. Inst. Meijo Univ. 4, 73-78 (2005).
2004
Midorikawa K., Uchida T., Okamoto Y., Toda C., Sakai Y., Ueda K., Hiraku Y., Murata M., Kawanishi S., Kojima N.: Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage. Chem. Biol. Interact. 150, 271-281 (2004). [PubMed]
Toda C., Okamoto Y., Ueda K., Hashizume K., Itoh K., Kojima N.: Unequivocal estrogen receptor-binding affinity of phthalate esters featured with ring hydroxylation and proper alkyl chain size. Arch. Biochem. Biophys. 431, 16–21 (2004). [PubMed]
Okamoto Y., Okajima K., Toda C., Ueda K., Hashizume K., Itoh K., Kojima N.: Novel estrogenic microsomal metabolites from phthalate esters. J. Health Sci. 50, 556-560 (2004). [J-Stage]
Okamoto Y., Toda C., Abe S., Hirose T., Ueda K., Hashizume K., Kojima N.: Products variation of phthalate esters in environmental biodegradation. J. Res. Inst. Meijo Univ. 3, 77-83 (2004).
2003
Okamoto Y., Toda C., Ueda K., Hashizume K., Itoh K., Kojima N.: Endocrine disrupting effects of plasticizers acquired by light-irradiation. J. Res. Inst. Meijo Univ. 2, 45-50 (2003).
Toda C., Uchida T., Midorikawa K., Murata M., Hiraku Y., Okamoto Y., Ueda K., Kojima N., Kawanishi S.: DNA damage by ethylbenzenhydroperoxide formed from carcinogenic ethylbenzene by sunlight irradiation. Biochem. Biophys. Res. Commun. 304, 638-642 (2003). [PubMed]
2002
Hashizume K., Nanya J., Toda C., Yasui T., Nagano H., Kojima N.: Phthalate esters detected in various water samples and biodegradation of the phthalates by microbes isolated from river water. Biol. Pharm. Bull. 25, 209-214 (2002). [PubMed]
Patents
2012
小嶋仲夫、岡本誉士典、高田達之（名城大学・立命館大学／共同出願）：ｄＣ、ｍｄＣ及び／又はｈｍｄＣを測定する方法（特開2012-233794）
2010
小嶋仲夫、西田博之、伊藤和男（名城大学）：セレノジスルフィド化合物及びその製造方法（特開2010-126483）
イベント2010年度