.

Yorinobu Yonezawa, Ph.D

SELECTED PUBLICATION

Dissolution and/or Release of Medicinal Substance
．
　§.　Release from or through a Wax Matrix System　　　　　　　　MEMO　　top
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　a modified Higuchi equation
１．Yorinobu Yonezawa, Sumio Ishida, Hisakazu Sunada：
　I.　Basic Release Properties of the Wax Matrix System
　Chem. Pharm. Bull., 49(11), 1448 - 1451 (2001)

２．Yorinobu Yonezawa, Sumio Ishida, Shinobu Suzuki, Hisakazu Sunada：
　II.　Basic Properties of Release from or through the Wax Matrix Layer
　Chem. Pharm. Bull., 50 (2), 220 - 224 (2002)

３．Yorinobu Yonezawa, Sumio Ishida, Shinobu Suzuki, Hisakazu Sunada：
　III.　Basic Properties of Release through the Wax Matrix Layer
　Chem. Pharm. Bull., 50 (6), 814 - 817 (2002)

４．Yorinobu Yonezawa, Sumio Ishida, Shinobu Suzuki, Hisakazu Sunada：
　IV.　Generalized Expression of the Release Process for a Reservoir Device Tablet
　Chem. Pharm. Bull., 50 (9), 1219 - 1222 (2002)

５．Yorinobu Yonezawa, Sumio Ishida, Hisakazu Sunada:
　V.　Applicability of the Square-Root Time Law Equation for Release from a Wax Matrix Tablet
　Chem. Pharm. Bull., 51 (8), 904- 908 (2003)

6．Yorinobu Yonezawa,  Sumio Ishida, Hisakazu Sunada:
　VI. Analysis and Prediction of the Entire Release Process of the Wax Matrix Tablet
　Chem. Pharm. Bull., 53( 8), 915 -918 (2005)

　§.　Release from or through a Polymer Matrix System

1) Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, and Hisakazu Sunada:
　 Analysis of the Release Process of Phenylpropranolamine Hydrochloridw from Ethylcellulose Matrix Granules
　 Chem. Pharm. Bull., 50 (11), 1439 - 1442 (2002)

2) Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, and Hisakazu Sunada:
　 Analysis of the Release Process of Phenylpropranolamine Hydrochloridw from Ethylcellulose Matrix Granules II
　 II. Effects of the Binder Solution on the Release Process
　 Chem. Pharm. Bull., 52 (3), 298 - 302 (2004)

3) Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, Hisakazu Sunada:
　　Analysis of Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules
　 III. Effects of the Dissolution Condition on the Release Process
　　Chem. Pharm. Bull., 54( 8), 1091 -1096 (2006)
4) Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, Hisakazu Sunada：
　　Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules .
　　 IV. Evaluation of the Controlled Release Properties for in Vivo and in Vitro Release Systems     
　　　Chem. Pharm. Bull., 55( 11), 1569 - 1573 (2007
5) Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, Hisakazu Sunada：
　　 Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules .
　　V. Release Properties of Ethylcellulose Layered Matrix Granules 
     　Chem. Pharm. Bull., 56(4), 525 - 529 (2008) 
　
．

　§.　Dissolution of Solid Dosage Form 　　　　　　　　　　　　　　　　　　　　　　　MEMO　　top
　　　　　　　　　　　　　　　　　　　　　　　　　　 an another derivation of Hixson-Crowell equations
1.　Yorinobu Yonezawa, Itaru Shinohara, Akinobu Otsuka, Hisakazu Sunada：
　Dissolution and Simulation Curves for Log-Normal Particle-Size-Distributed Model System
　Chem. Pharm. Bull., 38 (11), 3107 - 3111 (1990)

2.　Yorinobu Yonezawa, Kenji Shirakuara, Akinobu Otsuka, Hisakazu Sunada：
　II.　Equations for the Dissolution of Nondisintegrating Tablet under the Sink Condition
　Chem. Pharm. Bull., 39 (3), 769 - 772(1991)

3.　Yorinobu Yonezawa, Kenji Shirakuara, Akinobu Otsuka, Hisakazu Sunada：
　III.　Equations for the Dissolution of a Nondisintegrating Single Component Tablet under a Nonsink Condition
　Chem. Pharm. Bull., 39 (12), 3355 - 3358 (1991)

4.　Yorinobu Yonezawa, Itaru Shinohara, Midori Sasaki, Akinobu Otsuka, Hisakazu Sunada：
　IV.　Equations for the Non-sink Dissolution of a Monodisperse System.
　Chem. Pharm. Bull., 42 (2), 349 - 353 (1994)

5.　Yorinobu Yonezawa, Shuichi Kawase, Midori Sasaki, Itaru Shinohara, Hisakazu Sunada：
　V.　New Form Equations for the Non-sink Dissolution of a Monodisperse System
　Chem. Pharm. Bull., 43 (2), 304 -310 (1995)

6.　Yorinobu Yonezawa, Shuichi Kawase, Midori Sasaki, Akiko Wada, Hisakazu Sunada：
　VI.　Dissolution of Nondisintegrating Single Component Tablet under Non-Sink Condition
　Chem. Pharm. Bull., 43 (11), 1961 -1965 (1995)

7.　Yorinobu Yonezawa, Shuichi Kawase, Yuji Jinde, Hisakazu Sunada：
　VII.　Effect of Shape on the Dissolution of Nondisintegrating Single Component Tablet under Non-sink Condition
　Chem. Pharm. Bull., 44 (5), 1043 -1048 (1996)

1.　Hisakazu Sunada, Akio Yamamoto, Akinobu Otsuka, Yorinobu Yonezawa：　　　　　　　　　　　　　　　　　　　　　　 　　top
　Changes of Surface Area in the Dissolution Process of Crystalline Substances
　Chem. Pharm. Bull., 36 (7), 2557 - 2561 (1988)

2.　Hisakazu Sunada, Itaru Shinohara, Akinobu Otsuka, Yorinobu Yonezawa：
　II.　Dissolution and Simulation Curves for Mixed Systems of Sieved Particles
　Chem. Pharm. Bull., 37 (2), 467 - 470 (1989)

3.　Hisakazu Sunada, Itaru Shinohara, Akinobu Otsuka, Yorinobu Yonezawa：
　III.　Dissolution and Simulation curves for Symmetrical Particle-Size Distributed Model Systems 　
　Chem. Pharm. Bull., 37 (5), 1362 - 1365 (1989)

4.　Hisakazu Sunada, Itaru Shinohara, Akinobu Otsuka, Yorinobu Yonezawa：
　IV.　Dissolution and Simulation Curves Estimated from Changes of Surface Area and Cube Root Law
　Chem. Pharm. Bull., 37 (7), 1889 - 1894 (1989)

5.　Yorinobu Yonezawa, Itaru Shinohara, Akinobu Otsuka, Hisakazu Sunada：
　V.　Dissolution and Simulation Curves for Log-Normal Particle-Size-Distributed Model Systems
　Chem. Pharm. Bull., 38 (4), 1024 - 1026 (1990)

6.　Yorinobu Yonezawa, Itaru Shinohara, Akinobu Otsuka, Hisakazu Sunada：
　VI.　Simulation of Dissolution of Crystalline Particle
　J. Soc. Powder Tech., 27(9), 621-625 (1990)

7.　Yorinobu Yonezawa, Itaru Shinohara, Akinobu Otsuka, Hisakazu Sunada：
　VII.　Simulation of Dissolution of Crystalline Particle. II.
　J. Soc. Powder Tech., 28(9), 567-571 (1990)

Surface Chemistry
．
　§.　Physico-Chemical Properties of Glycyrrhizic Acid in Aqueous Media 　　　　　MEMO　　top

1.　Akinobu Otsuka, Yorinobu Yonezawa, Katsuhie Iba, Tsuneji Tatsumi, Hisakazu Sunada：
　Surface-active Properties and Formulation of Molecular Aggregates
　Yakugaku Zasshi, 96 (2), 203 - 208 (1976)

2.　Akinobu Otsuka, Yorinobu Yonezawa, Yasuhiko Nakamura：
　Effect on Flocculation-Deflocculation Behavior of Suspensions of Sulfathiazole and Graphite
　J. Pharm. Sci., 67 (2), 151 - 154 (1978)

3.　Yorinobu Yonezawa, Akinobu Otsuka：
　Solubilizing Properties for Dyes and Medicinal Substance
　Yakugaku Zasshi, 101 (9), 829 - 835 (1981)

4.　Yorinobu Yonezawa, Akinobu Otsuka：　Emulsification of Oleic Acid
　Yakugaku Zasshi, 103 (2), 203 - 208 (1983)

5.　Yorinobu Yonezawa, Hisakazu Sunada, Akinobu Otsuka, Masayuki Nakagaki：
　Critical Micelle Concentration of Mixed Solution of Glycyrrhizin and Sodium Cholate
　Yakugaku Zasshi, 103 (10), 1085 - 1090 (1983)

6.　Yorinobu Yonezawa, Akinobu Otsuka, Hisakazu Sunada：
　Emulsifying Ability of Glycyrrhizin and Stability of the Emulsion
　J. Jpn. Cosmet. Sci. Soc., 8 (1), 61 - 66 (1984)
　

1. Jens Thuro Carstensen, Yorinobu Yonezawa：
　Dissolution Profiles in Column Dissolution
　J. Pharm. Sci., 75 (8), 764 - 768 (1986)

2.　Hisakazu Sunada, Yoshiko Hirai, Yorinobu Yonezawa, Akinobu Otsuka：
　Flocculation Studies of Granulated Stearyl Alcohol on the Surface of Aqueous Media.II.
　Flocculation-Deflocculation Mechanism in a Two-Dimensional System
　Chem. Pharm. Bull., 36 (9), 3584 -3588 (1988)

3.　Hisakazu Sunada, Yumiko Takahashi, Takashi Kurimoto, Yoshiko Hirai, Yorinobu Yonezawa, Akinobu Otsuka, Yoshiaki Kawashima：
　Flocculation Studies of Granulated Stearyl Alcohol on the Surface of Aqueous Media. III.
　Changes of Agglomerate Structure in a Two-Dimensional System with Anionic Surface-Active Agent.
　Chem. Pharm. Bull., 37(12), 3355-3558(1989)

4.　Kimpei Yamamoto, Hisakazu Sunada, Yorinobu Yonezawa, Akinobu Otsuka：
　Relationship between the fluorescence intensities and physico-chemical properties of gallium and aluminium chelate of 2-hydroxyphenylazomethine
　and 2,2'-dihydroxyazobenzene derivatives
　Bunseki Kagaku, 40, 465-498 (1991)

5.　Haruo Sekizaki, Kazumi Danjo, Hiroshi Eguchi, Yorinobu Yonezawa, Hisakazu Sunada, Akinobu Otsuka：
　Solid-State Interaction of Ibuprofen with Polyvinyl-pyrrolidone
　Chem. Pharm. Bull., 43 (6), 988 - 993 (1995)

6.　Yunxia Bi, Hisakazu Sunada, Yorinobu Yonezawa, Kazumi Danjo, Akinobu Otsuka, Kotaro Iida：
　Preparation and Evaluation of a Compress Tablet Rapidly Disintegrating in the Oral Cavity.
　Chem. Pham. Bull., 44(11), 2121-2127 (1996)

7.　Yasuhiro Shimada, Mayu Sunada, Mari Mizuno, Yorinobu Yonezawa, Hisakazu Sunada, Kei Takebayashi, Masahiko Yokosuka, Haruki Kimura:
　Measurement of the adhesive force of fine particle on tablet surface and method of their removal
　Drug Development and Industrial Pharmacy, 26(2), 149-158 (2000)

8. Yasuhiro Shimada, Yorinobu Yonezawa, Hisakazu Sunada,
　Measurement and Evakuation of the Adhesive Force between Particles by the Direct Separation Method
　J. Pharm. Sci., 92( 3), 526-534 (2003)

Lecture
Undergraduate School Course：
　Physical Chemistry
　Dissolution-Analysis and Simulation
　Release -Analysis and Simulation

Education
B.Ph.：Kyoto Univ.(1967),
Ph.D.：Kyoto Univ.(1983),　　Faculty Member：Meijo University (1967 - )
Visiting Scholar：Univ. of Wisconsin Madison, School of Pharmacy (1983 - 1985)
　

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