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　Yrinobu Yonezawa, Ph.D

　　PAGE for COLLABORATION
　　PAGE for MEMORANDUM
　　PAGE for

　　PUBLICATION / FIELD 　　　[JPN]　　　　　　　　　　　　　　　　　　　in preparation 　　　　Jan. '12

.　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　entrance
§I.　SURFACE CHEMISTRY

�@） Physico-Chemical Properties of Glycyrrhizic Acid in Aqueous Media　　　　　[ MEMO ]
　２．Akinobu Otsuka, Yorinobu Yonezawa, Katsuhide Iba, Tsuneji Tatsumi, Hisakazu Sunada:
　　　Physico-Chemical Properties of Glycyrrhizic Acid in Aqueous Media.
　　　I. Surface-active Properties and Formation of Melecular Aggregates
　　　YAKUGAKU ZASSHI, 96 (2), 203 - 208 (1976)
　３．Akinobu Otsuka, Yorinobu Yonezawa, Yasuhiko Nakamura,
　　　Physico-Chemical Properties of Glycyrrhizic Acid in Aqueous Media.
　　　II. Effect on Flocculation-Deflocculation Behavior of Suspensions of Sulfathiazole and Graphite    
　　　J. Pharm. Sci., 67 (2), 151 - 154 (1978)
　６．Yorinobu Yonezawa, Akinobu Otsuka:
　　　Physico-Chemical Properties of Glycyrrhizic Acid in Aqueous Media.
　　　III. Solubilizing Properties for Dyes and Medicinal Substance
　　　YAKUGAKU ZASSHI, 101 (9), 829 - 835 (1981)
　７．Yorinobu Yonezawa, Akinobu Otsuka:
　　　Physico-Chemical Properties of Glycyrrhizic Acid in Aqueous Media.
　　　IV. Emulsification of Oleic Acid
　　　YAKUGAKU ZASSHI, 103 (2), 203 - 208 (1983)
　８．Yorinobu Yonezawa, Hisakazu Sunada, Akinobu Otsuka, Msayuki Nakagaki:
　　　Physico-Chemical Properties of Glycyrrhizic Acid in Aqueous Media.
　　　V. Critical Micelle Concentration of Mixed Solution of Glycyrrhizin and Sodium Cholate
　　　YAKUGAKU ZASSHI, 103 (10), 1085 - 1090 (1983)
　10．Yorinobu Yonezawa, Akinobu Otsuka, Hisakazu Sunada:
　　　Emulsifying Ability of Glycyrrizin and Stability of the Emulsions
　　　J. Jpn Cosmet. Sci. Soc., 8 (1), 61 - 66 (1984)
　４．Akinobu Otsuka, Yorinobu Yonezawa, Junko Watanabe:
　　　Determination of Critical Micelle Concentration of Sodium Cholate by Iodine Method
　　　YAKUGAKU ZASSHI, 99 (2), 217 - 219 (1979)

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§II.　INTERACTION

�@）Flocculation-Deflocculation
　１．Akinobu Otsuka, Hisakazu Sunada, Yorinobu Yonezawa,
　　　Adsorption of Nonionic Surfactants on Sulfathiazole and Naphthalene and Flocculation-
　　　Deflocculation Behavior of These Suspensions 
  　　J. Pharm. Sci., 62 (5), 751-754 (1973)

�A）Flocculation-Deflocculation in a Two-Dimensional System
　14．Hisakazu Sunada, Yoshiko Hirai, Akinobu Otsuka, Yorinobu Yonezawa,
　　　Flocculation Studies of Granulated Stearyl Alcohol on the Surface of Aqueous Media.
　　　II. Flocculation-Deflocculation Mechanism in a Two-Dimensional System
　　　Chem. Pharm. Bull., 36 (9), 3584 - 3588 (1988)
　18．Hisakazu Sunada, Yumiko Takahashi, Takashi Kurimoto, Yoshiko Hirai, Yorinobu Yonezawa,
　　　Akinobu Otsuka, Yoshiaki Kawashima,
　　　Flocculation Studies of Granulated Stearyl Alcohol on the Surface of Aqueous Media.  
　　　III. Changes of Aggromerate Structure in a Two-Dimensional System with Anionic Surface-Active Agent  
　　　Chem. Pharm. Bull., 37 (12), 3355 - 3358 (1989)

�B）Flocculation Kinetics of the Monodisperse System
　32．Yoshihiro Aoki, Yoshiharu Yamada, Kazumi Danjo, Yorinobu Yonezawa, Hisakazu Sunada,
　　　Flocculation Kinetics of the Monodisperse System. II.
　　　Computer Simulation of Flocculation with Compaction by the Two-Dimensional Geometrical Random Coalescence Model
　　　Chem. Pharm. Bull., 43 (7), 1197 -1203 (1995)

�C）Solid-State Interaction
　31．Haruo Sekizaki, Kazumi Danjo, Hiroshi Eguchi, Yorinobu Yonezawa, Hisakazu Sunada, Akinobu Otsuka,
　　　Solid-State Interaction of Ibuprofen with Polyvinylpyrrolidone
　　　Chem. Pharm. Bull., 43 (6), 988 - 993 (1995)
　46．Masatoshi OZAWA, Koji HASEGAWA, Yorinobu YONEZAWA, Hisakazu SUNADA
　　　Preparation of Solid Dispersion for Ethenzamide-Carbopol and Theophyline-Carbopol SystemUsing a Twin Screw Extruder
　　　Chem. Pharm. Bull., 50( 6),  802 - 807 (2002)

�D）Fluorescence Intensities and Physico-chemical Properties
　５．Kimpei Yamamoto, Hisakazu Sunada, Yorinobu Yonezawa, Akinobu Otsuka:
　　　Application of Free-Wilsons's Analitycal Method to the Fluorescence Intensities of Aluminum Chelate of 2-hydroxyazomethine Derivatives
　　　BUNSEKI KAGAKU, 28, 205-208 (1979)
　22．Kimpei Yamamoto, Hisakazu Sunada, Yorinobu Yonezawa, Akinobu Otsuka:
　　　Relationship between the fluorescence intensities and physico-chemical properties of Gallium and alminiumchelates of
　　　2-hydroxyphenylazomethine and 2,2'-dihydroxyazobenzene derivatives
　　　BUNSEKI KAGAKU, 40(9), 495-498 (1991)

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§III.　Dissolution & Release

�@） Changes of Surface Area in the Dissolution Process of Crystalline Substances　　　　　[ MEMO ]
　13．Hisakazu Sunada, Akio Yamamoto, Akinobu Otsuka, Yorinobu Yonezawa,
　　　Changes of Surface Area in the Dissolution Process of Crystalline Substances
　　　Chem. Pharm. Bull., 36 (7), 2557 - 2561 (1988)   
　15．Hisakazu Sunada, Itaru Shinohara, Akinobu Otsuka, Yorinobu Yonezawa,
　　　Changes of Surface Area in the Dissolution Process of Crystalline Substances.
　　　II. Dissolution and Simulation Curves for Mixed Systems of Sieved Particles
　　　Chem. Pharm. Bull., 37 (2), 467 - 470 (1989)
　16．Hisakazu Sunada, Itaru Shinohara, Akinobu Otsuka, Yorinobu Yonezawa,
　　　Changes of Surface Area in the Dissolution Process of Crystalline Substances.
　　　III. Dissolution and Simulation curves for Symmetrical Particle-Size Distributed Model Systems
　　　Chem. Pharm. Bull., 37 (5), 1362 - 1365 (1989)
　17．Hisakazu Sunada, Itaru Shinohara, Akinobu Otsuka, Yorinobu Yonezawa,
　　　Changes of Surface Area in the Dissolution Process of Crystalline Substances.
　　　IV. Dissolution and Simulation Curves Estimated from Changes of Surface Area and Cube Root Law
　　　Chem. Pharm. Bull., 37 (7), 1889 - 1894 (1989)
　19．Yorinobu Yonezawa, Itaru Shinohara, Akinobu Otsuka, Hisakazu Sunada,
　　　Changes of Surface Area in the Dissolution Process of Crystalline Substances.
　　　V. Dissolution and Simulation Curves for Log-Normal Particle-Size-Distributed Model Systems
　　　Chem. Pharm. Bull., 38 (4), 1024 - 1026 (1990)
　Tech.１．Yorinobu Yonezawa, Itaru Shinohara, Akinobu Otsuka, Hisakazu Sunada:
　　　Simulation of Dissolution of Crystalline Particle　
　　　FUNTAIKOUGAKUKAISHI, 27(9), 621-625 (1990)
　Tech. ２．Yorinobu Yonezawa, Itaru Shinohara, Akinobu Otsuka, Hisakazu Sunada:
　　　Simulation of Dissolution of Crystalline Particle (II)
　　　FUNTAIKOUGAKUKAISHI, 28(9), 567-571 (1991)

�A） Dissolution of Solid Dosage Form　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　[ MEMO ]
　　　　　　　　　　　　　　　　　　　　　　　　　　　an another derivation of Hixson-Crowell equations
　20．Yorinobu Yonezawa, Itaru Shinohara, Akinobu Otsuka, Hisakazu Sunada,
　　　Dissolution and Simulation Curves for Log-Normal Particle-Size-Distributed Model System  
　　　Chem. Pharm. Bull., 38 (11), 3107 - 3111 (1990)
　21．Yorinobu Yonezawa, Kenji Shirakuara, Akinobu Otsuka, Hisakazu Sunada,
　　　Dissolution of Solid Dosage Form.
　　　II. Equations for the Dissolution of Nondisintegrating Tablet under the Sink Condition    
　　　Chem. Pharm. Bull., 39 (3), 769 - 772 (1991)
　23．Yorinobu Yonezawa, Kenji Shirakuara, Akinobu Otsuka, Hisakazu Sunada,
　　　Dissolution of Solid Dosage Form.
　　　III. Equations for the Dissolution of a Nondisintegrating Single Component Tablet under a Nonsink Condition  
　　　Chem. Pharm. Bull., 39 (12), 3355 - 3358 (1991)
　27．Yorinobu Yonezawa, Itaru Shinohara, Midori Sasaki, Akinobu Otsuka, Hisakazu Sunada,
　　　Dissolution of Solid Dosage Form.
　　　IV. Equations for the Non-sink Dissolution of a Monodisperse System
　　　Chem. Pharm. Bull., 42 (2), 349 - 353 (1994)
　29．Yorinobu Yonezawa, Shuichi Kawase, Midori Sasaki, Itaru Shinohara, Hisakazu Sunada,
　　　Dissolution of Solid Dosage Form.
　　　V. New Form Equations for the Non-sink Dissolution of a Monodisperse System
　　　Chem. Pharm. Bull., 43 (2), 304 -310 (1995)
　33．Yorinobu Yonezawa, Shuichi Kawase, Midori Sasaki, Akiko Wada, Hisakazu Sunada,
　　　Dissolution of Solid Dosage Form.
　　　VI. Dissolution of Nondisintegrating Single Component Tablet under Non-Sink Condition
　　　Chem. Pharm. Bull., 43 (11), 1961 -1965 (1995)
　34．Yorinobu Yonezawa, Shuichi Kawase, Yuji Jinde, Hisakazu Sunada,
　　　Dissolution of Solid Dosage Form.
　　　VII. Effect of Shape on the Dissolution of Nondisintegrating Single Component Tablet under Non-sink Condition  
　　　Chem. Pharm. Bull., 44 (5), 1043 -1048 (1996)

�B） Release from or through a Wax Matrix System　　　　　　　　　[ MEMO ]
　28．Yasutomi Kato, Hisakazu Sunada, Yorinobu Yonezawa, Ryuzo Ishino,
　　　Sustained Release Mechanisms of Wax Matrix System for Controlled Release
　　　Chem. Pharm. Bull., 42 (8), 1646 - 1650 (1994)
　44．Yorinobu Yonazawa,  Sumio Ishida,  Hisakazu Sunada
　　　Release from or through a Wax Matrix System.
　　　I. Basic Release Properties of the Wax Matrix System
　　　Chem. Pharm. Bull., 49(11), 1448 - 1451 (2001)
　45．Yorinobu Yonazawa,  Sumio Ishida,  Shinobu Suzuki, Hisakazu Sunada
　　　Release from or through a Wax Matrix System.
　　　II. Basic Properties of Release from or through the Wax Matrix System
　　　Chem. Pharm. Bull., 50( 2),    220 -   224 (2002)
　47．Yorinobu Yonazawa,  Sumio Ishida,  Shinobu Suzuki, Hisakazu Sunada
　　　Release from or through a Wax Matrix System.
　　　III. Basic Properties of Release through the Wax Matrix System
　　　Chem. Pharm. Bull., 50( 6),    814 -   817 (2002)
　48．Yorinobu Yonezawa,  Sumio Ishida,  Shinobu Suzuki, Hisakazu Sunada
　　　Release from or through a Wax Matrix System.
　　　IV. Generalized Expression of Release Process for Reservoir Device Tablet
　　　Chem. Pharm. Bull., 50( 9), 1219 - 1222 (2002)
　58．Yorinobu Yonezawa,  Sumio Ishida, Hisakazu Sunada:
　　　Release from or through a Wax Matrix System.
　　　V. Applicability of Square-Root Time Law Equation for Release from a Wax Matrix Tablet
　　　Chem. Pharm. Bull., 51( 8), 904 -908 (2003)
　62．Yorinobu Yonezawa,  Sumio Ishida, Hisakazu Sunada:
　　　Release from or through a Wax Matrix System.
　　　VI. Analysis and Prediction of the Entire Release Process of the Wax Matrix Tablet
　　　Chem. Pharm. Bull., 53( 8), 915 -918 (2005)

�C） Release from or through a Polymer Matrix System
　50．Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, Hisakazu Sunada:
　　　Analysis of Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules   
　　　Chem. Pharm. Bull., 50(11), 1439 -11442 (2002)
　61．Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, and Hisakazu Sunada:
　　　Analysis of the Release Process of Phenylpropranolamine Hydrochloridw from Ethylcellulose Matrix Granules
　　　II. Effects of the Binder Solution on the Release Process
　　　Chem. Pharm. Bull., 52 (3), 298 - 302 (2004)
　68．Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, Hisakazu Sunada:
　　Analysis of Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules
　　III.Effects of the Dissolution Condition on the Release Process
　　Chem. Pharm. Bull., 54(8), 1091 -1096 (2006)
　74．Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, Hisakazu Sunada：
　　 Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules
　　 IV. Evaluation of the Controlled Release Properties for in Vivo and in Vitro Release Systems     
　　Chem. Pharm. Bull., 55( 11), 1569 - 1573 (2007
　76．Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, Hisakazu Sunada：
　　Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules .
　　V. Release Properties of Ethylcellulose Layered Matrix Granules 
     Chem. Pharm. Bull., 56(4), 525 - 529 (2008) 

�D） Tablet Rapidly Disintegrating in the Oral Cavity
　35．Yunxia Bi, Hisakazu Sunada, Yorinobu Yonezawa, Kazumi Danjo, Akinobu Otsuka, Kotarou Iida,
　　　Preparation and Evaluation of a Compressed Tablet Rapidly Disintegrating in the Oral Cavity  
　　　Chem. Pharm. Bull., 44 (11), 2121 -2127 (1996)
　37．Yunxia Bi, Hisakazu Sunada, Yorimobu Yonezawa, Kazukmi Danjo,
　　　Evaluation of Rapidly Disintegrationg Tablets Prepared by a Direct Compression Method
　　　Drug Development and Industrial Pharmacy, 25(5), 571-581 (1999)
　39．Yunxia Bi, Yorinobu Yonezawa, Hisakazu Sunada,
　　　Rapidly Disintegrating Tablets Prepared by the Wet Compression Method: Mechanism and Optimization  
　　　J. Pharm. Sci., 88(10), 1004-1010 (1999)
　66．Yoko Yamada, Mariko Nakamura, Yasuhiro Shimada, Yorinobu Yonezawa, Hisakazu Sunada:
　　Preparation and Evaluation of Rapidly Disintegrating Tablet in the Oral Cavity by the Dry Compression Method
　　- Availability of Powdered Cellulose as an Excipient -
　　YAKUZAIGAKU, 66(6), 473 -481 (2006)


�E） Column Dissolution
　11．Jens Thuro Carstensen, Yorinobu Yonezawa,
　　　Dissolution Profiles in Column Dissolution    
　　　J. Pharm. Sci., 75 (8), 764 -768 (1986) 

.　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　entrance
§IV.　Pharmaceutical Technology

�@） Excipient &
　38．Kenta Goto, Hisakazu Sunada, Kazumi Danjo, Yorinobu Yonezawa,
　　　Pharmaceutical Evaluation of Multipurpose Excipients for Direct Compressed Tablet
　　　Manufacture: Comparison of the Capabilities of Multipurpose Excipients with Those in General Use  
　　　Drug Development and Industrial Pharmacy, 25(8), 869-878 (1999)
　49．Miho Kimura, Yasuhiro Shimada, Takao Oshima, Daichi Shibata, Naoto Hattori, Yorinobu Yonezawa, Hisakazu Sunada:
　　　The Evaluation of Powdered Cellulose as a Pharmaceutical Excipient
　　　YAKUZAIGAKU, 62(3),113-123 (2000)
　51．Daichi Shibata, Yasuhiro Shimada, Yorinobu Yonezawa, Hisakazu Sunada, Naoya Otomo, Kenji Kasahara:
　　　Application and Evaluation of Sucrose Fatty Acid Esters as Lubricants in the Production of Pharmaceuticals    
　　　YAKUZAIGAKU, 62(4), 133-145 (2002)

�A） Granulation
　42．Takeshi Kawaguchi, Hisakazu Sunada, Yorinobu Yonezawa, Kazumi Danjo, Masaki Hasegawa,
　　　Tadashi Makino, Hiroshi Sakamoto, Kanji Fujita, Tadatugu Tanino, Hiroyasu Kokubo:
　　　Granulation of Acetaminophen by a Rotating Fluidized-Bed Granulator
　　　Pharmaceutical Development and Technology, 5 (2), 141- 151 (2000)

�B） Pharmaceutical Preparation of Crude Drug Powder
　24．Li Xiaoman, Yorinobu Yonezawa, Kazumi Danjo, Hisakazu Sunada, Noboru Matsui:
　　　Secondary Granulation of Senna Powder by Agitation Method
　　　YAKUZAIGAKU, 53(1), 63-69 (1993)
　25．Hideo Yamaguchi, Yorinobu Yonezawa, Kazumi Danjo, Hisakazu Sunada, Noritaka Seko, Ryuzo Ishino:
　　　Relationship between Characteristics of Powder and Granule on Granulation of Senna Powder
　　　YAKUZAIGAKU, 53(1), 70-79 (1993)
　26．Noritaka Seko, Hisakazu Sunada, Kazumi Danjo, Akinobu Otsuka, Yorinobu Yonezawa, Noboru Matsui,
　　　Pharmaceutical Preparation of Crude Drug Powder. III.
　　　The Effect of the Physical Properties of the Binder Solution on the Characteristics of the Granule from the Mixed Powders   
　　　Chem. Pharm. Bull., 41 (5), 937 - 941 (1993)
　30．Hideo Yamaguchi, Hisakazu Sunada, Yorinobu Yonezawa, Kazumi Danjo:
　　　Relationship between Characteristics of Raw Materials and Its Products of Crude Drug Powder
　　　YAKUZAIGAKU, 55(1), 17-27 (1995)
　65．Koh Konishi, Hisakazu Sunada, Yorinobu Yonezawa, Kazumi Danjo:
　　　Pharmaceutical Manufacturing of Crude Drug Powder - Dry Compacting Method with a Roller Compactor -
　　　YAKUZAIGAKU, 66(2), 151 -159 (2006)

�C） Particle Designation
　36．Masami Tasaka, Sunada, Yorinobu Yonezawa:
　　　Characterization of Core Particles for Film Cating with High Active Ingredient Content
　　　YAKUZAIGAKU, 59(2), 57-66(1999)
　59．Xiaoyan Wang, Fude Cui, Yorinobu Yonezawa, Hisakazu Sunada,
　　　Preparation and Evaluation of Combination Tablet Containing
　　　- Granulation and Layering to Prevent Incompatibility -
　　　YAKUZAIGAKU, 63(4), 207 -217 (2003)
　60．Xiaoyan Wang, Fude Cui, Yorinobu Yonezawa, Hisakazu Sunada,
　　　Preparation and Evaluation of High Drug Content Particles
　　　Drug Development and Industrial Pharmacy, 29(10), 1109-1118 (2003)
　

�D） Adhesive Force of Fine Particles
　40．Yasuhiro Shimada, Tatsuya Ito, Yorinobu Yonezawa, Hisakazu Sunada, Masahiko Yokosuka, Kei Takebayashi:
　　　Measurements of the Adhesive Force of Contaminative Particles on the Capsule Surface and Method of Their Removal     
　　　YAKUZAIGAKU, 60(1), 35-42 (2000)
　41．Yasuhiro Shimada, Mayu Sunada, Mari Mizuno, Yorinobu Yonezawa, Hisakazu Sunada, Kei Takebayashi, Masahiko Yokosuka, Haruki Kimura:
　　　Measurement of the adhesive force of fine particles on tablet surface and method of their removal     
　　　Drug Development and Industrial Pharmacy, 26(2), 149-158 (2000)
　43．Yasuhiro Shimada, Yorinobu Yonezawa, Hisakazu Sunada, Ryusei Nonaka, Kenzo Kato, Hiroshi Morishita:
　　　The Development of an Apparatus for Measuring the Adhesive Force betwen Fine Particles　
　　　J. Soc. Powder Technol., Japan,  37(9), 28-34 (2000)
　52．Yasuhiro Shimada, Yorinobu Yonezawa, Hisakazu Sunada,
　　　Measurement and Evaluation of the Adhesive Force between Particles by the Direct Separation Method
　　　J. Pharm. Sci., 92( 3), 526-534 (2003)
　5６．Yasuhiro Shimada, Yorinobu Yonezawa, Hisakazu Sunada
　　表面改質法を用いた微小粒子間付着力の制御とその評価
　　J. Soc. Powder Technol., Japan,  40(5), 334-338 (2003)

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§V.　Pharmacy & Bioactivity

　９．Yasuo Nakamoto, Toshiyuki Takeeda, Etsuko Kamiya, Kazuhiro Morimoto, Masahide Yasuda, Katsuaki Morishita, Yorinobu Yonezawa, Akinobu Otsuka,
　　　ENHANCEMENT OF LYMPHATIC TRANSPORT OF 1-(2-TETRA-HYDROFURYL)-5-FLUORO-URACIL BY POLYACRYLIC ACID AQUEOUS GEL
　　　AND EMULSION TYPE SUPPOSITORIES IN RAT
　　　J. Pharm. Dyn., 6, 637-642 (1983)
　12．Hisakazu Sunada, Manabu Sugimoto, Yorinobu Yonezawa, Akinobu Otsuka:
　　　Relationship between Bioactivity and Physico-Chemical Properties of Indoprofen and Its Related Compounds   
　　　YAKUZAIGAKU, 48(1), 58-63 (1988)

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