研究業績

2017年

学会報告

伊藤優里、石原永梨、森下真衣、佐藤匡史、田中啓二、加藤晃一、栗本英治
ヒト20SプロテアソームシャペロンPAC4のX線結晶構造解析
日本生化学会中部支部第81回例会・シンポジウム(名古屋)平成29年5月20日

仲吉朝希、福吉修一、高橋央宜、栗本英治、小田彰史
リン酸触媒によるセリン残基の非酵素的反応:デヒドロアラニン残基生成機構の量子化学計算
第63回日本薬学会東海支部大会(岐阜)平成29年7月8日

前田航平、伊藤優里、角田潤、夏秋正岳、小田彰史、栗本英治
サブユニットの一本鎖化を応用したヒト20S プロテアソーム形成メカニズムの解析
第63回日本薬学会東海支部大会(岐阜)平成29年7月8日

Tomoki Nakayoshi, Shuichi Fukuyoshi, Ohgi Takahashi, Eiji Kurimoto, Akifumi Oda
Computational Studies on Water‐Catalyzed Stereoinversion Mechanism of Glutamic Acid Residues in Peptides and Proteins
Chirality 2017; 29th International Symposium on Chirality(Tokyo)平成29年7月10日

Akifumi Oda, Tomoki Nakayoshi, Shuichi Fukuyoshi, Eiji Kurimoto, Noriyuki Yamaotsu, Shuichi Hirono, Ohgi Takahashi
Validation of molecular force field parameters for D-amino acids using quantum chemical calculations of model peptides
Chirality 2017; 29th International Symposium on Chirality(Tokyo)平成29年7月11日

Shuichi Fukuyoshi, Yoshie Hayami, Yurie Watanabe, Akifumi Oda
Experimental and Computational Study on Photoreaction of Flutamide and Its Cyano Analogue
XXIX IUPAP Conference on Computational Physics(Paris, France)平成29年7月10日-11日

Tomoki Nakayoshi, Shuichi Fukuyoshi, Koichi Kato, Ohgi Takahashi, Eiji Kurimoto, Akifumi Oda
Computational studies on cyclic imide formation mechanism of glutamic acid residues catalyzed by two water molecules
XXIX IUPAP Conference on Computational Physics(Paris, France)平成29年7月10日-11日

Akifumi Oda, Koichi Kato, Mayu Morino, Tomoki Nakayoshi, Shuichi Fukuyoshi, Ken Saijo, Chikashi Ishioka, Eiji Kurimoto
Prediction of three-dimensional structures of histone deacetylase 1 complexed with romidepsin and its analog
XXIX IUPAP Conference on Computational Physics(Paris, France)平成29年7月10日-11日

Yurie Watanabe, Koichi Kato, Shuichi Fukuyoshi, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Hiroaki Gouda, Akifumi Oda
Effect of the Arg456His mutation on the threedimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations
XXIX IUPAP Conference on Computational Physics(Paris, France)平成29年7月10日-11日

Yurie Watanabe, Akifumi Oda, Hiroaki Gouda
Molecular dynamics study of interaction between PACAP (6'-38') and N-terminal extracellular domain of the human splice variant hPAC1-R-short aiming at development of neuropathic pain medicine
XXIX IUPAP Conference on Computational Physics(Paris, France)平成29年7月10日-11日

Koichi Kato, Kenichiro Fujii, Tomoki Nakayoshi, Yurie Watanabe, Shuichi Fukuyoshi, Kiminori Ohta, Yasuyuki Endo, Noriyuki Yamaotsu, Shuichi Hirono, Eiji Kurimoto, Akifumi Oda
Structural differences of the ligand binding pockets between estrogen receptor alpha and beta
XXIX IUPAP Conference on Computational Physics(Paris, France)平成29年7月10日-11日

Akifumi Oda, Tomoki Nakayoshi, Shuichi Fukuyoshi, Eiji Kurimoto, Ohgi Takahashi
Influences of conformations of peptides on stereoinversions and/or isomerizations of aspartic acid residues
The 3rd International Conference of D-Amino Acid Research (Varese, Italy)平成29年7月10日-12日

Tomoki Nakayoshi, Shuichi Fukuyoshi, Ohgi Takahashi, Eiji Kurimoto, Akifumi Oda
Quantum chemical studies on nonenzymatic repair mechanism of isomerized aspartic acid residues
The 3rd International Conference of D-Amino Acid Research (Varese, Italy)平成29年7月10日-12日

Shuichi Fukuyoshi, Akufumi Oda, Ohgi Takahashi, Tomoki Nakayoshi
Computational study on bond formation of a primitive protein including D-amino acid
The 3rd International Conference of D-Amino Acid Research (Varese, Italy)平成29年7月10日-12日

Koichi Kato, Yukiho Shimizu, Eiji Kurimoto, Akifumi Oda
Analysis of functional segments in the coiled coil domains of yeast cargo receptors Emp46p/47p and application to pH sensitive devices
19th International Union of Pure and Applied Biophysics and 11th European Biophysical Societies' Association Congress(Edinburgh, UK)平成29年7月19日

仲吉朝希、福吉修一、加藤紘一、高橋央宜、栗本英治、小田彰史
密度汎関数法によるグルタミン酸残基の立体反転の検討
第15回次世代を担う若手のためのフィジカル・ファーマフォーラム(金沢)平成29年9月4日(若手研究者奨励賞)

加藤紘一、古橋隆久、栗本英治、小田彰史
酵母輸送タンパク質Emp46p/47pのコイルドコイルの会合メカニズム解析とpH依存性改変
第15回次世代を担う若手のためのフィジカル・ファーマフォーラム(金沢)平成29年9月5日(若手研究者奨励賞)

成田瑶子、菱沼英史、齋藤さかえ、安田純、長﨑正朗、前川正充、小田彰史、平澤典保、平塚真弘
日本人2049人の全ゲノム解析から同定された8種のDHPレアバリント活性変化
第56回日本薬学会東北支部大会(青森)平成29年10月21日

原著論文

Eiji Kurimoto, Tadashi Satoh, Yuri Ito, Eri Ishihara, Kenta Okamoto, Maho Yagi-Utsumi, Keiji Tanaka, Koichi Kato
Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation
Protein Sci., 26, 1080-1085 (2017).

Yurie Watanabe, Shuichi Fukuyoshi, Koichi Kato, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Hiroaki Gouda, Akifumi Oda
Investigation of substrate recognition for cytochrome P450 1A2 mediated by water molecules using docking and molecular dynamics simulations
J. Mol. Graph. Model., 74, 326-336 (2017).

Eiji Hishinuma, Fumika Akai, Yoko Narita, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
Functional characterization of 21 allelic variants of dihydropyrimidinase
Biochem. Pharmacol., 143, 118-128 (2017).

Koichi Kato, Tomoki Nakayoshi, Shuichi Fukuyoshi, Eiji Kurimoto, Akifumi Oda
Validation of molecular dynamics simulations for prediction of three-dimensional structures of small proteins
Molecules, 22, 1716 (2017).

Akifumi Oda, Shuichi Fukuyoshi, Eiji Kurimoto
Determination of molecular force field parameters for nitronyl nitroxide derivatives using quantum chemical calculations
Polyhedron, 136, 93-101 (2017).

Tomohiro Yoshida, Tatsuki Fukami, Takaya Kurokawa, Saki Gotoh, Akifumi Oda, Miki Nakajima
Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans
Eur. J. Pharm. Sci., 111, 167-176 (2018).

Masaki Kumondai, Hiroki Hosono, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
Functional characterization of 9 CYP2A13 allelic variants by assessment of nicotine C-oxidation and coumarin 7-hydroxylation
Drug Metab. Pharmacokinet., in press.

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