生理学研究室 ( PHYSIOLOGY )
| 教授 | 湯川和典（Professor Kazunori Yukawa, M. D. & Ph. D. ） |
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| 助教 | 吉田 謙二（Assistant Professor Kenji Yoshida, Ph. D. ） |
| 助教 | 根岸 隆之（Assistant Professor Takayuki Negishi, D. V. M. & Ph. D. ） |
| ① | 軸索ガイダンス分子セマフォリンの新規作用機構の研究 |
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| ② | アポトーシス関連分子DAPKの新規作用機構の研究 |
| ③ | 遺伝性白内障モデルラット（ICR/f）が呈する尿崩症の原因に関する研究 |
| ④ | 1型糖尿病の発症機構と治療法開発に関する研究 |
| ⑤ | 発達期脳における環境中化学物質曝露の影響評価に関する研究 |
| Erika Sawano, Takayuki Negishi, Tomoyuki Aoki, Masami Murakami, Tomoko Tashiro：Alterations in local thyroid hormone signaling in the hippocampus of the senescence-accelerated mouse prone 8 (SAMP8) at younger ages: association with delayed myelination and behavioral abnormalities. J. Neurosci. Res. , 91(3), 382-392 (2013) |
| Stefan Freigang, Elise Landais, Victoria Zadorozhny, Lisa Kain, Kenji Yoshida, Yang Liu, Shenglou Deng, Wulf Palinski, Paul B. Savage, Albert Bendelac, and Luc Teyton：Scavenger receptors target glycolipids for natural killer T cell activation. J. Clin. Invest. , 122(11), 3943–3954 (2012) |
| Takayuki Negishi, Masaki Takahashi, Yuki Matsunaga, Seishiro Hirano, Tomoko Tashiro：Diphenylarsinic Acid Increased Synthesis and Release of Neuroactive and Vasoactive Peptides in Rat Cerebellar Astrocytes. J. Neuropath. Exp. Neurol. , 71(6), 468-479 (2012) |
| Yuki Iwasaki, Takayuki Negishi, Makoto Inoue, Tomoko Tashiro, Takeshi Tabira, Nobuyuki Kimura：Sendai virus vector-mediated BDNF expression ameliorates memory deficits and synaptic degeneration in a transgenic mouse model of Alzheimer’s disease. J. Neurosci. Res. , 90(5), 981-989 (2012) |
| Tetsuji Tanaka, Tao Bai, Hirotoshi Utsunomiya, Takahiro Fukumoto and Kazunori Yukawa：STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells. Mol. Med. Rep. , 4(2), 307-312 (2011) |
| Kenji Yoshida, Adam L. Corper, Rana Herro, Bana Jabri, Ian A. Wilson and Luc Teyton：The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity. J. Clin. Invest. , 120(5), 1578-1590 (2010) |
| Kazunori Yukawa, Tetsuji Tanaka, Masanori Kishino, Kenji Yoshida, Noriko Takeuchi, Takuji Ito, Hyota Takamatsu, Hitoshi Kikutani, and Atsushi Kumanogoh：Deletion of Sema4D gene reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Int. J. Mol. Med. , 26(1), 39-44 (2010) |
| Tao Bai, Tetsuji Tanaka and Kazunori Yukawa：Targeted knockdown of death-associated protein kinase expression induces TRAIL-mediated apoptosis in human endometrial adenocarcinoma cells. Int. J. Oncol. , 37(1), 203-210 (2010) |
| Tetsuji Tanaka, Tao Bai and Kazunori Yukawa：Death-associated protein kinase is essential for the survival of various types of uterine cancer cells. Int. J. Oncol. , 37(4), 1017-1022 (2010) |
| Kazunori Yukawa, Tetsuji Tanaka, Kenji Yoshida, Noriko Takeuchi, Takuji Ito, Hyota Takamatsu, Hitoshi Kikutani, and Atsushi Kumanogoh：Sema4A induces cell morphological changes through B-type plexin-mediated signaling. Int. J. Mol. Med. , 25(2), 225-230 (2010) |
| Kazunori Yukawa, Tetsuji Tanaka, Noriko Takeuchi, Hiroyuki Iso, Li Li, Akira Kohsaka, Hidefumi Waki, Masayasu Miyajima, Masanobu Maeda, Hitoshi Kikutani, and Atsushi Kumanogoh：Sema4D/CD100 deficiency leads to superior performance in mouse motor behavior. Can. J. Neurol. Sci. , 36(3), 349-355 (2009) |
| Li Li, Tetsuji Tanaka, Kazunori Yukawa, Shizuo Akira and Naohiko Umesaki：Irinotecan-induced ovarian follicular apoptosis is attenuated by deleting the kinase domain of death-associated protein kinase. Int. J. Oncol. , 34(4), 905-914 (2009) |
| Akiko Nakagami, Takayuki Negishi (equal first-author), Katsuyoshi Kawasaki, Noritaka Imai, Yoshiro Nishida, Toshio Ihara, Yoichiro Kuroda, Yasuhiro Yoshikawa, Takamasa Koyama：Alterations in male infant behaviors towards its mother by prenatal exposure to bisphenol A in cynomolgus monkeys (Macaca fascicularis) during early suckling period. Psychoneuroendocrinology, 34, 1189-1197 (2009) |
| Masaki Takahashi, Takayuki Negishi, Makoto Imamura, Erika Sawano, Yoichiro Kuroda, Yasuhiro Yoshikawa, Tomoko Tashiro：Alterations in gene expression of glutamate receptors and exocytosis-related factors by a hydroxylated-polychlorinated biphenyl in the developing rat brain. Toxicology, 257, 17-24 (2009) |
| Zara Hovhannisyan, Angela Weiss, Alexandra Martin, Martina Wiesner, Stig Tollefsen, Kenji Yoshida, Cezary Ciszewski, Shane A. Curran, Joseph A. Murray, Chella S. David, Ludvig M. Sollid, Frits Koning, Luc Teyton and Bana Jabri：The role of HLA-DQ8 β57 polymorphism in the anti-gluten T-cell response in coeliac disease. Nature. , 456(7221), 534-538 (2008) |